AB-22
AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in Candida albicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis.
For research use only. We do not sell to patients.
- CAS No.: 1463913-43-0
- Formula: C22H30ClN7O3
- Molecular Weight:475.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AB-22 (4 μg/mL; 30-120 mins) delays germ tube formation of SC5314 cells[1].
AB-22 (0.25-3 h) inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in SC5314 cells[1].
AB-22 (0.5-4 μg/mL; 24 hours) inhibits hyphal growth of SC5314 cells[1].
AB-22 (1-4 μg/mL; 24 hours) inhibits biofilm formation of SC5314 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice infected with C. albicans ATCC90028 cells (male, 7-weeks-old)[1]
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Dosage:20 and 30 mg/kg, twice a day for 5 days or 300 mg/kg for a single dose
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Administration:Orally administration
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Result:Prolonged survival time and increased survival rate.
Chemical Information
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CAS No. 1463913-43-0
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Molecular Weight 475.97
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Formula C22H30ClN7O3
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SMILES
O=C(NN(CCO)C1=CC(C(C)C)=C(C(C)=NN2C)C2=N1)NC3=CC(OCCC)=NC(Cl)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AB-22 Related Classifications
HY-178732 Related Classifications
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