AI10-a2
AI10-a2 is a tyrosinase (tyrosinase) inhibitor, with IC50 values of 0.92 μM against mushroom tyrosinase using L-DOPA (HY-N0304) as the substrate and 0.68 μM using L-Tyrosine (HY-N0473) as the substrate. AI10-a2 inhibits intracellular melanin (melanin) production and reduces head pigmentation in zebrafish embryos. AI10-a2 can be used for the research of hyperpigmentation disorders.
For research use only. We do not sell to patients.
- Formula: C19H23N3O3
- Molecular Weight:341.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AI10-a2 (12.5-100 μM) inhibits melanogenesis in B16F10 cells stimulated by Melanotan (MT)-II (HY-P0267) in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type AB strain (embryos at 6 h postfertilization)[1]
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Dosage:30 μM; 60 μM
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Administration:immersion; continuous; 45 h
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Result:Achieved a depigmentation efficacy of 12.68% at 60 μM.
Showed minimal to negligible toxicity in treated embryos.
Chemical Information
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Molecular Weight 341.40
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Formula C19H23N3O3
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SMILES
CC1=CC(C(N2CCN(CC2)CC3=CC=C(C=C3O)O)=O)=CC(C)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AI10-a2 Related Classifications
HY-184909 Related Classifications
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