IFNG - interferon gamma Gene
Also Known as IFG; IFI; IMD69
Species: Homo sapiens
About IFNG
This gene has 1 transcript (splice variant), 172 orthologues and is associated with 8 phenotypes. Biased expression in bone marrow (RPKM 3.6), lymph node (RPKM 3.2) and 8 other tissues.
Summary
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, Bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
IFNG Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000619.3 | NP_000610.2 | interferon gamma precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cytokine activity |
IDA
IDA: Inferred from direct assay
|
16914093 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7617032 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular region |
IDA
IDA: Inferred from direct assay
|
20041150 | GOA |
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
16914093 | GOA |
IFNG Protein Structure
IFN-gamma: Interferon gamma (15 - 152)
- 0
- 100
- 166 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interferon gamma |
|
IFNG Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
IFNG | P01579 | IFNGR1 | Homo sapiens | P15260 | 7617032 | |
|
Intra
|
IFNG | P01579 | IFNGR1 | Homo sapiens | P15260 | 33961781 | |
|
Intra
|
IFNG | P01579 | IFNGR1 | Homo sapiens | P15260 | 28514442 | |
|
Cross
|
IFNG | P01579 | C4R | Ectromelia virus | Q66793 | 18252829 | |
|
Cross
|
IFNG | P01579 | C4R | Ectromelia virus | Q66793 | 18252829 |
Recombinant IFNG Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7025 | IFN-gamma Protein, Human | P01579 (Q24-Q166) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7025A | IFN-gamma Protein, Human (CHO) | P01579 (Q24-Q166) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P70610 | IFN-gamma Protein, Human (HEK293) | P01579 (Q24-Q166) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70610G | GMP IFN-gamma Protein, Human (HEK293) | P01579 (Q24-Q166) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78140 | IFN-gamma Protein, Human (Biotinylated, HEK293, His-Avi) | P01579 (Q24-G161) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78456 | IFN-gamma Protein, Human (HEK293, His-Avi) | P01579 (Q24-G161) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78552 | GMP IFN-gamma Protein, Human | P01579 (Q24-Q166) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700091AF | Animal-Free IFN-gamma Protein, Human (His) | P01579 (Q24-Q166) | ≥ 95%, as determined by reducing SDS-PAGE. |
IFNG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81111 | IFN gamma Antibody (YA3520) | WB, ICC/IF, FC | Human, Mouse, Rat |
| HY-P81111A | IFN gamma Antibody (YA3520)(PBS only) | WB, ICC/IF, FC | Human, Mouse, Rat |
| HY-P85211 | IFN gamma Antibody (YA4903) | WB, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Immunodeficiency 69 |
|
|
| Hepatitis C Virus |
|
|
| Tuberous Sclerosis 2 |
|
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| Aplastic Anemia |
|
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| Human Immunodeficiency Virus Type 1 |
|
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| Cutaneous Leishmaniasis |
|
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| Pulmonary Tuberculosis |
|
|
| Lepromatous Leprosy |
|
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| Tetanus |
|
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| Pulmonary Sarcoidosis |
|
|
| Tuberous Sclerosis 1 |
|
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| Tropical Spastic Paraparesis |
|
|
| Histoplasmosis |
|
|
| Colitis |
|
|
| Tuberculoid Leprosy |
|
|
| Chronic Granulomatous Disease |
|
|
| Allergic Disease |
|
|
| Disease By Infectious Agent |
|
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| Ulcerative Colitis |
|
|
| Leishmaniasis |
|
|
| Visceral Leishmaniasis |
|
|
| Chronic Beryllium Disease |
|
|
| Folliculitis |
|
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| Alopecia Areata |
|
|
| Scleritis |
|
|
| Schistosomiasis |
|
|
| Cytomegalovirus Retinitis |
|
|
| Pleural Tuberculosis |
|
|
| Peanut Allergy |
|
|
| Graft-Versus-Host Disease |
|
|
| Hyper Ige Syndrome |
|
|
| Cryptococcosis |
|
|
| Uveitis |
|
|
| Malaria |
|
|
| Poliomyelitis |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Acute Graft Versus Host Disease |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| Graves Ophthalmopathy |
|
|
| Plasmodium Falciparum Malaria |
|
|
| Erythema Nodosum |
|
|
| Hepatitis B |
|
|
| Lymphadenitis |
|
|
| Viral Infectious Disease |
|
|
| Ocular Tuberculosis |
|
|
| Autoimmune Disease |
|
|
| Graves' Disease |
|
|
| Strongyloidiasis |
|
|
| Myocarditis |
|
|
| Q Fever |
|
|
| Allergic Asthma |
|
|
| Toxic Shock Syndrome |
|
|
| Toxoplasmosis |
|
|
| Leishmaniasis, Tegumentary |
|
|
| Erythema Multiforme |
|
|
| Berylliosis |
|
|
| Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
|
|
| Herpes Zoster |
|
|
| Proliferative Glomerulonephritis |
|
|
| Helicobacter Pylori Infection |
|
|
| Hepatitis C |
|
|
| Echinococcosis |
|
|
| Inflammatory Bowel Disease |
|
|
| Eosinophilia-Myalgia Syndrome |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Clonorchiasis |
|
|
| Brucellosis |
|
|
| Monocytic Leukemia |
|
|
| Bacterial Infectious Disease |
|
|
| Mucormycosis |
|
|
| Viral Meningitis |
|
|
| Polyradiculoneuropathy |
|
|
| Pelvic Inflammatory Disease |
|
|
| Allergic Rhinitis |
|
|
| Sporotrichosis |
|
|
| Myasthenia Gravis |
|
|
| Pleurisy |
|
|
| Dermatitis |
|
|
| Paratyphoid Fever |
|
|
| Bronchiolitis Obliterans |
|
|
| Panniculitis |
|
|
| Sarcoidosis 1 |
|
|
| Demyelinating Disease |
|
|
| Penicillin Allergy |
|
|
| Smallpox |
|
|
| Contact Dermatitis |
|
|
| Trypanosomiasis |
|
|
| Chronic Fatigue Syndrome |
|
|
| Hemophagocytic Lymphohistiocytosis |
|
|
| Paracoccidioidomycosis |
|
|
| Cd40 Ligand Deficiency |
|
|
| Filariasis |
|
|
| Extrapulmonary Tuberculosis |
|
|
| Typhoid Fever |
|
|
| Intestinal Tuberculosis |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Fascioliasis |
|
|
| Castleman Disease |
|
|
| Pericarditis |
|
|
| Scrub Typhus |
|
|
| Mouth Disease |
|
|
| Allergic Contact Dermatitis |
|
|
| Meningitis |
|
|
| Allergic Conjunctivitis |
|
|
| Osteomyelitis |
|
|
| Fasciitis |
|
|
| Dermatitis, Atopic |
|
|
| Multiple Sclerosis |
|
|
| Tonsillitis |
|
|
| Bronchiolitis |
|
|
| Conjunctivitis |
|
|
| Allergic Bronchopulmonary Aspergillosis |
|
|
| Rubella |
|
|
| Hepatitis A |
|
|
| Neuritis |
|
|
| Melioidosis |
|
|
| Subacute Sclerosing Panencephalitis |
|
|
| Necrotic Uveal Melanoma |
|
|
| Brawny Scleritis |
|
|
| Chlamydia |
|
|
| Lichen Planus |
|
|
| Type 1 Diabetes Mellitus |
|
|
| Leptospirosis |
|
|
| Cyclic Neutropenia |
|
|
| Multidrug-Resistant Tuberculosis |
|
|
| Miliary Tuberculosis |
|
|
| Meconium Aspiration Syndrome |
|
|
| Immune Deficiency Disease |
|
|
| Hand, Foot And Mouth Disease |
|
|
| Periodontitis |
|
|
| Aspergillosis |
|
|
| Abdominal Tuberculosis |
|
|
| Hepatitis E |
|
|
| Carotid Artery Thrombosis |
|
|
| Lymphangioma |
|
|
| Hidradenitis Suppurativa |
|
|
| Severe Acute Respiratory Syndrome |
|
|
| Gastrointestinal Tuberculosis |
|
|
| Appendicitis |
|
|
| Keratoconjunctivitis |
|
|
| Food Allergy |
|
|
| Rheumatoid Arthritis |
|
|
| Endocarditis |
|
|
| Lymphopenia |
|
|
| Gastroenteritis |
|
|
| Thyroiditis |
|
|
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
|
| Pericardial Tuberculosis |
|
|
| Purpura |
|
|
| Skeletal Tuberculosis |
|
|
| Hidradenitis |
|
|
| Mixed Connective Tissue Disease |
|
|
| Severe Combined Immunodeficiency |
|
|
| Influenza |
|
|
| Candida Glabrata |
|
|
| Chagas Disease |
|
|
| Spondylitis |
|
|
| Central Nervous System Tuberculosis |
|
|
| Asthma |
|
|
| Psoriasis |
|
|
| Mumps |
|
|
| Cryoglobulinemia |
|
|
| Histiocytosis |
|
|
| Gingivitis |
|
|
| Rheumatic Fever |
|
|
| Otitis Media |
|
|
| Ileus |
|
|
| Omenn Syndrome |
|
|
| Osteoporosis |
|
|
| Hashimoto Thyroiditis |
|
|
| Bronchiectasis |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Viral Hepatitis |
|
|
| Aggressive Periodontitis |
|
|
| Pemphigoid |
|
|
| Lymph Node Tuberculosis |
|
|
| Pulmonary Emphysema |
|
|
| Skin Disease |
|
|
| Sezary'S Disease |
|
|
| Interstitial Lung Disease |
|
|
| Pancytopenia |
|
|
| Tuberculous Peritonitis |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Candidiasis |
|
|
| Connective Tissue Disease |
|
|
| Arthritis |
|
|
| Rhinitis |
|
|
| Colorectal Cancer |
|
|
| Alcoholic Hepatitis |
|
|
| Diphtheria |
|
|
| Biliary Atresia |
|
|
| Stomatitis |
|
|
| Brain Edema |
|
|
| Pustular Psoriasis |
|
|
| Pyelonephritis |
|
|
| Hypereosinophilic Syndrome |
|
|
| Autoimmune Hepatitis |
|
|
| Interstitial Lung Disease 2 |
|
|
| Skin Sarcoidosis |
|
|
| Inclusion Body Myositis |
|
|
| Pneumonia |
|
|
| Prostatitis |
|
|
| Diarrhea |
|
|
| Combined Immunodeficiency |
|
|
| Temporal Arteritis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Carotid Stenosis |
|
|
| Macs Syndrome |
|
|
| Coccidiosis |
|
|
| Retinal Detachment |
|
|
| Arteriosclerosis |
|
|
| Alopecia |
|
|
| Angelucci'S Syndrome |
|
|
| Common Variable Immunodeficiency |
|
|
| Peritonitis |
|
|
| Ige Responsiveness, Atopic |
|
|
| Myositis |
|
|
| Posterior Scleritis |
|
|
| Mycosis Fungoides |
|
|
| Urticaria |
|
|
| Lymphoid Interstitial Pneumonia |
|
|
| Major Depressive Disorder |
|
|
| Chorioretinitis |
|
|
| Suppurative Lymphadenitis |
|
|
| Fungal Meningitis |
|
|
| Osteopetrosis |
|
|
| Cholera |
|
|
| Fuchs' Heterochromic Uveitis |
|
|
| Lung Disease |
|
|
| Cryptococcal Meningitis |
|
|
| Gingival Overgrowth |
|
|
| Pancreatic Cancer |
|
|
| Friedreich Ataxia |
|
|
| Hypersensitivity Reaction Type Iv Disease |
|
|
| Penicilliosis |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Primary Systemic Mycosis |
|
|
| Neutropenia |
|
|
| Cervical Adenitis |
|
|
| Scleral Disease |
|
|
| Choroiditis |
|
|
| Inflammatory Bowel Disease 4 |
|
|
| Anterior Scleritis |
|
|
| Central Nervous System Vasculitis |
|
|
| Melanoma |
|
|
| Intermediate Uveitis |
|
|
| Benzylpenicillin Allergy |
|
|
| Tuberculous Encephalopathy |
|
|
| Lung Abscess |
|
|
| Epidural Abscess |
|
|
| Laryngeal Tuberculosis |
|
|
| Chickenpox |
|
|
| Leprosy 3 |
|
|
| Esophageal Tuberculosis |
|
|
| Panophthalmitis |
|
|
| Mycoplasma Pneumoniae Pneumonia |
|
|
| Urogenital Tuberculosis |
|
|
| Fungal Infectious Disease |
|
|
| Immunodeficiency 27a |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Pneumocystosis |
|
|
| Latent Syphilis |
|
|
| Constrictive Pericarditis |
|
|
| Heart Disease |
|
|
| Lichen Disease |
|
|
| Coronavirus Infectious Disease |
|
|
| Neuroretinitis |
|
|
| Relapsing Polychondritis |
|
|
| Histoplasmosis Meningitis |
|
|
| Severe Covid-19 |
|
|
| Aortitis |
|
|
| Anterior Uveitis |
|
|
| Hyperglobulinemic Purpura |
|
|
| Hydrocephalus |
|
|
| Phagocyte Bactericidal Dysfunction |
|
|
| Viral Exanthem |
|
|
| Chondromalacia |
|
|
| Thrombocytopenia |
|
|
| Lymph Node Disease |
|
|
| Muscular Atrophy |
|
|
| Arachnoiditis |
|
|
| Exanthem |
|
|
| Opportunistic Mycosis |
|
|
| Acute Retinal Necrosis Syndrome |
|
|
| West Nile Encephalitis |
|
|
| Viral Pneumonia |
|
|
| Laryngeal Squamous Cell Carcinoma |
|
|
| Necrotizing Ulcerative Gingivitis |
|
|
| Splenic Disease |
|
|
| Panuveitis |
|
|
| Aphthous Stomatitis |
|
|
| Spondyloarthropathy |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Integumentary System Disease |
|
|
| Pericardium Disease |
|
|
| Congenital Toxoplasmosis |
|
|
| Nose Disease |
|
|
| Cryptosporidiosis |
|
|
| Herpangina |
|
|
| Commensal Bacterial Infectious Disease |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Conjunctival Disease |
|
|
| Bladder Tuberculosis |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Nasal Cavity Disease |
|
|
| Bronchial Disease |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Bacterial Pneumonia |
|
|
| Uveal Disease |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Cystic Fibrosis |
|
|
| Parasitic Helminthiasis Infectious Disease |
|
|
| Lung Cancer |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Diabetes Mellitus |
|
|
| Myocardial Infarction |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Bone Inflammation Disease |
|
|
| Crohn'S Disease |
|
|
| Sarcoid Meningitis |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Trimethoprim Allergy |
|
|
| Salmonellosis |
|
|
| Autism Spectrum Disorder |
|
|
| Leukocyte Disease |
|
|
| Immunodeficiency 27b |
|
|
| Severe Cutaneous Adverse Reaction |
|
|
| Neuroblastoma |
|
|
| Behcet Syndrome |
|
|
| Gastric Cancer |
|
|
| Celiac Disease 1 |
|
|
| Ovarian Cancer |
|
|
| Respiratory Failure |
|
|
| Blood Platelet Disease |
|
|
| Hypertension, Essential |
|
|
| Breast Cancer |
|
|
| Autism |
|
|
| Schizophrenia |
|
|
| Peripheral Nervous System Disease |
|
|
| Eye Disease |
|
|
| Nervous System Disease |
|
|
| Leukemia, Acute Myeloid |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | IFNG | MGD | MGI:107656 |
| Macaca mulatta | IFNG | VGNC | VGNC:73568 |
| Bos taurus | IFNG | VGNC | VGNC:30057 |
| Canis familiaris | IFNG | VGNC | VGNC:41879 |
| Rattus norvegicus | IFNG | RGD | RGD:2866 |
| Felis catus | IFNG | VGNC | VGNC:67703 |
| Others | IFNG | NCBI |