JMS-17-2
Based on 18 publication(s) in Google Scholar
JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells.
For research use only. We do not sell to patients.
- Purity: 99.18%
- CAS No.: 1380392-05-1
- Formula: C25H26ClN3O
- Molecular Weight:419.95
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Anti-Cancer Compound Library
HY-L025
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Endocrinology Compound Library
HY-L047
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Anti-Breast Cancer Compound Library
HY-L074
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Targeted Diversity Library
HY-L099
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Chemokine Compound Library
HY-L132
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Heterocyclic Compound Library
HY-L138
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Membrane Protein-targeted Compound Library
HY-L149
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HY-L150
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) JMS-17-2
More- Cancer Discov. 2025 Jun 18:OF1-OF16. [Abstract]
- Cancer Res. 2022 Nov 15;82(22):4206-4218. [Abstract]
- Nat Commun. 2024 Jan 10;15(1):449. [Abstract]
- Neuron. 2026 Jan 21;114(2):237-249.e10. [Abstract]
- Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]
- Cancer Lett. 2024 Mar 31:585:216674. [Abstract]
- J Neuroinflammation. 2023 Mar 21;20(1):81. [Abstract]
- PLoS Biol. 2026 Jan 20;24(1):e3003538. [Abstract]
- Cell Rep. 2024 Feb 17;43(2):113804. [Abstract]
- Cell Prolif. 2025 May 25:e70061. [Abstract]
- Food Funct. 2024 Feb 19;15(4):1948-1962. [Abstract]
- Sci Rep. 2026 Feb 15;16(1):9169. [Abstract]
- Microbiol Spectr. 2025 Nov 13:e0234125. [Abstract]
- Heliyon. 2024 Apr 1;10(7):e29100. [Abstract]
- Stem Cells Int. 2023 Feb 20:2023:6400162. [Abstract]
- Placenta. 2024 Aug 21:156:30-37. [Abstract]
- Exp Ther Med. 2023 Jun 7;26(1):359. [Abstract]
- bioRxiv. 2025 Oct 17:2025.10.17.683060. [Abstract]
Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Cell Migration/Invasion Assay
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In Vivo Efficacy Study
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Histological Imaging/Staining
Biological Activity
IC50: 0.32 nM (CX3CR1)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice (~25g) with MDA-231 xenograft[1]
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Dosage:10 mg/kg
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Administration:Aministered i.p.; twice a day for three weeks
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Result:Caused a dramatic reduction of tumors in both skeleton and visceral organs.
Chemical Information
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CAS No. 1380392-05-1
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Appearance Solid
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Molecular Weight 419.95
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Formula C25H26ClN3O
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Color White to off-white
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SMILES
O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (18)
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Journal Impact Factor
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Most Recent
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Cancer Discov
Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype. [Abstract]2025 Jun 18:OF1-OF16. PMID: 40530504
JMS-17-2 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Jun 18:OF1-OF16. [Abstract]
JMS-17-2 (10 mg/kg; IP; five times per week ) combination with αPD-1 led to a dramatic inhibition of tumor growth in C57BL/6 mice.
JMS-17-2 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Jun 18:OF1-OF16. [Abstract]
JMS-17-2 (10 mg/kg; IP; five times per week ) combination with αPD-1 significantly decreased in NK cell abundance at the tumor rim and an increased infiltration of CD45+ immune cells (including CD8+ T cells) in C57BL/6 mice.
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Cancer Res
Postoperative plasmacytoid dendritic cells secrete IFN-α to promote recruitment of myeloid-derived suppressor cells and drive hepatocellular carcinoma recurrence. [Abstract]2022 Nov 15;82(22):4206-4218. PMID: 36112065 -
Nat Commun
Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice. [Abstract]2024 Jan 10;15(1):449. PMID: 38200023 -
Neuron
Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance. [Abstract]2026 Jan 21;114(2):237-249.e10. PMID: 41570802 -
Gut Microbes
Fusobacterium nucleatum-driven CX3CR1+ PD-L1+ phagocytes route to tumor tissues and reshape tumor microenvironment. [Abstract]2025 Dec;17(1):2442037. PMID: 39710592
JMS-17-2 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]
JMS-17-2 (10 nM; 1+12 h) significantly inhibited both Fn- and Fn1792-stimulated PMNs migration to endothelial cells.
JMS-17-2 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]
JMS-17-2 (10 mg/kg; IP; daily) attenuated the stimulating effects of Fn1792 on tumor progression in MC38 tumor-bearing C57BL/6 mice.
JMS-17-2 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]
JMS-17-2 (10 mg/kg; IP; daily) decreased the Fn1792 induced the number of lung metastatic in MC38 tumor-bearing C57BL/6 mice. Representative images of H&E staining of lung and quantitative analysis.
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Cancer Lett
Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3cl1 axis. [Abstract]2024 Mar 31:585:216674. PMID: 38280480 -
J Neuroinflammation
Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain. [Abstract]2023 Mar 21;20(1):81. PMID: 36944965 -
PLoS Biol
Microglial activity during postnatal development is required for infantile amnesia in mice. [Abstract]2026 Jan 20;24(1):e3003538. PMID: 41557596 -
Cell Rep
A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation. [Abstract]2024 Feb 17;43(2):113804. PMID: 38368612 -
Cell Prolif
Repetitive Transcranial Magnetic Stimulation Induces Cognitive Recovery in Alzheimer's Disease via GABAergic Neuron Activation of the Cx3cl1-Cx3cr1 Axis. [Abstract]2025 May 25:e70061. PMID: 40415257 -
Food Funct
Resveratrol inhibits respiratory syncytial virus replication by targeting heparan sulfate proteoglycans. [Abstract]2024 Feb 19;15(4):1948-1962. PMID: 38270052 -
Sci Rep
Chronic inflammation promotes gastric cancer progression via ADAM10-mediated cleavage of CX3CL1. [Abstract]2026 Feb 15;16(1):9169. PMID: 41691064 -
Microbiol Spectr
New insight into the epidemiological trends of respiratory syncytial virus infection and the underlying anti-respiratory syncytial virus mechanisms of andrographolide: integrating Global Burden of Disease database, network pharmacological analysis, and in vitro experiments. [Abstract]2025 Nov 13:e0234125. PMID: 41230964 -
Heliyon
CX3CL1 and its receptor CX3CR1 interact with RhoA signaling to induce paclitaxel resistance in gastric cancer. [Abstract]2024 Apr 1;10(7):e29100. PMID: 38601629 -
Stem Cells Int
Nucleus Pulposus Cells Induce M2 Polarization of RAW264.7 via CX3CL1/CX3CR1 Pathway and M2 Macrophages Promote Proliferation and Anabolism of Nucleus Pulposus Cells. [Abstract]2023 Feb 20:2023:6400162. PMID: 37274023
JMS-17-2 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2023 Feb 20:2023:6400162. [Abstract]
CX3CL1 remarkably induces M2 polarization of RAW264.7 , while this effect is measurably reversed by JMS-17-2.
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Placenta
High expression of CX3CL1/CX3CR1 at the mother-fetus interface of preeclampsia inhibits trophoblast invasion and migration. [Abstract]2024 Aug 21:156:30-37. PMID: 39236525 -
Exp Ther Med
CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization. [Abstract]2023 Jun 7;26(1):359. PMID: 37324510 -
bioRxiv
2025 Oct 17:2025.10.17.683060. PMID: 41279042
Solvent & Solubility
DMSO : 41.67 mg/mL (99.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3812 mL | 11.9062 mL | 23.8124 mL | 59.5309 mL |
| 5 mM | 0.4762 mL | 2.3812 mL | 4.7625 mL | 11.9062 mL | |
| 10 mM | 0.2381 mL | 1.1906 mL | 2.3812 mL | 5.9531 mL | |
| 15 mM | 0.1587 mL | 0.7937 mL | 1.5875 mL | 3.9687 mL | |
| 20 mM | 0.1191 mL | 0.5953 mL | 1.1906 mL | 2.9765 mL | |
| 25 mM | 0.0952 mL | 0.4762 mL | 0.9525 mL | 2.3812 mL | |
| 30 mM | 0.0794 mL | 0.3969 mL | 0.7937 mL | 1.9844 mL | |
| 40 mM | 0.0595 mL | 0.2977 mL | 0.5953 mL | 1.4883 mL | |
| 50 mM | 0.0476 mL | 0.2381 mL | 0.4762 mL | 1.1906 mL | |
| 60 mM | 0.0397 mL | 0.1984 mL | 0.3969 mL | 0.9922 mL | |
| 80 mM | 0.0298 mL | 0.1488 mL | 0.2977 mL | 0.7441 mL |
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