2. PROTAC
  3. Ligands for E3 Ligase
  4. VHL Ligand 35

VHL Ligand 35 (Compound 14) is a von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase ligand with a Kd of 0.291 μM. VHL Ligand 35 disrupts protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α).

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VHL Ligand 35

VHL Ligand 35 Chemical Structure

CAS No. : 1631137-31-9

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VHL Ligand 35 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

VHL Ligand 35 (Compound 14) is a von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase ligand with a Kd of 0.291 μM. VHL Ligand 35 disrupts protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α)[1].

IC50 & Target[1]

VHL

0.291 μM (Kd)

Molecular Weight

619.78

Formula

C33H41N5O5S
CAS No.
SMILES

C([C@@H](NC([C@H](CC1=CC=CC=C1)NC(C)=O)=O)C(C)(C)C)(=O)N2[C@H](C(NCC3=CC=C(C=C3)C4=C(C)N=CS4)=O)C[C@@H](O)C2
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Purity & Documentation
References
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VHL Ligand 35 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

VHL Ligand 351631137-31-9VHL Ligand35VHL Ligand-35Ligands for E3 LigaseE3 ligase-recruiting MoietyE3 ubiquitin ligaseLHS2 subpockethypoxia inducible factor 1α (HIF-1α)VHL-ElonginB-ElonginC complexvon Hippel-Lindau protein (pVHL)LHS1 subpocketInhibitorinhibitorinhibit

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VHL Ligand 35
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