VHL Ligand 35
VHL Ligand 35 (Compound 14) is a von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase ligand with a Kd of 0.291 μM. VHL Ligand 35 disrupts protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α).
For research use only. We do not sell to patients.
- CAS No.: 1631137-31-9
- Formula: C33H41N5O5S
- Molecular Weight:619.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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VHL 0.291 μM (Kd) |
Chemical Information
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CAS No. 1631137-31-9
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Molecular Weight 619.78
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Formula C33H41N5O5S
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SMILES
C([C@@H](NC([C@H](CC1=CC=CC=C1)NC(C)=O)=O)C(C)(C)C)(=O)N2[C@H](C(NCC3=CC=C(C=C3)C4=C(C)N=CS4)=O)C[C@@H](O)C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1].
Galdeano C, et al. Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. J Med Chem. 2014 Oct 23;57(20):8657-63.
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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