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  3. VU0420373

VU0420373 

Cat. No.: HY-115658
Handling Instructions

VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus.

For research use only. We do not sell to patients.

VU0420373 Chemical Structure

VU0420373 Chemical Structure

CAS No. : 38376-29-3

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1].

IC50 & Target

EC50: 10.7 μM (HssRS)[1]
pEC50: 4.97 (HssRS)[1]

In Vitro

VU0420373 (compound 2e) has an IC50 of >60 μM for Newman aerobic and Newman anaerobic, respectively[1].
VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

254.26

Formula

C15H11FN2O

CAS No.
SMILES

OC1=CC=CC=C1C2=NNC(C3=CC=CC=C3F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Product Name:
VU0420373
Cat. No.:
HY-115658
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