WNK-IN-11-d3
Based on 1 Customer Validation
WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 2123483-49-6
- Formula: C21H18D3Cl2N5OS
- Molecular Weight:465.41
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
WNK[1]
WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice[1].
WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg[1].
WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague−Dawley rats[1]
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Dosage:1.5 mg/kg
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Administration:P.o.
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Result:Showed an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability.
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Animal Model:FVB mice[1]
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Dosage:30 mg/kg
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Administration:P.o.
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Result:Showed significant reductions in systolic blood pressure (SBP) vs untreated mice.
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Animal Model:FVB mice[1]
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Dosage:0~100 mg/kg
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Administration:P.o.
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Result:Induced dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2123483-49-6
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Unlabeled Cas 2123489-30-3
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Appearance Solid
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Molecular Weight 465.41
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Formula C21H18D3Cl2N5OS
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Color Off-white to light yellow
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SMILES
O=C(N1CCN(CC1)CC2=CC=C(C=C2)Cl)C3=CC(C4=CSC(NC([2H])([2H])[2H])=N4)=NC=C3Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (214.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1486 mL | 10.7432 mL | 21.4864 mL | 53.7161 mL |
| 5 mM | 0.4297 mL | 2.1486 mL | 4.2973 mL | 10.7432 mL | |
| 10 mM | 0.2149 mL | 1.0743 mL | 2.1486 mL | 5.3716 mL | |
| 15 mM | 0.1432 mL | 0.7162 mL | 1.4324 mL | 3.5811 mL | |
| 20 mM | 0.1074 mL | 0.5372 mL | 1.0743 mL | 2.6858 mL | |
| 25 mM | 0.0859 mL | 0.4297 mL | 0.8595 mL | 2.1486 mL | |
| 30 mM | 0.0716 mL | 0.3581 mL | 0.7162 mL | 1.7905 mL | |
| 40 mM | 0.0537 mL | 0.2686 mL | 0.5372 mL | 1.3429 mL | |
| 50 mM | 0.0430 mL | 0.2149 mL | 0.4297 mL | 1.0743 mL | |
| 60 mM | 0.0358 mL | 0.1791 mL | 0.3581 mL | 0.8953 mL | |
| 80 mM | 0.0269 mL | 0.1343 mL | 0.2686 mL | 0.6715 mL | |
| 100 mM | 0.0215 mL | 0.1074 mL | 0.2149 mL | 0.5372 mL |
WNK-IN-11-d3 Related Classifications
HY-112094S Related Classifications
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