2. Inhibitory Antibodies
  3. XmAb 5592

XmAb 5592 is a humanized, Fc-engineered anti-HM1.24 antibody with enhanced binding to FcγRIIIa and FcγRIIa receptors, augments HM1.24-specific multiple myeloma (MM) cells lysis in vitro via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP).

For research use only. We do not sell to patients.

XmAb 5592 Chemical Structure

XmAb 5592 Chemical Structure

CAS No. : 1221901-33-2

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Description

XmAb 5592 is a humanized, Fc-engineered anti-HM1.24 antibody with enhanced binding to FcγRIIIa and FcγRIIa receptors, augments HM1.24-specific multiple myeloma (MM) cells lysis in vitro via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP)[1].

In Vitro

XmAb 5592 (0-1000 ng/mL) enhances antibody-dependent cellular cytotoxicity (ADCC) and ntibody dependent cellular phagocytosis (ADCP) against multiple myeloma (MM) cells. XmAb 5592 significantly augments ADCC relative to the IgG1 analog against all cell lines ranged from 5-27 ng/mL, also augments antibody dependent cellular phagocytosis (ADCP) by macrophages[1].
XmAb 5592 (0-10000 ng/mL) induces strong MM cell lysis by degranulation of NK cells even in the presence of bone marrow stromal cells (BMSCs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XmAb 5592 Related Antibodies
In Vivo

XmAb 5592 (0.3-9 mg/kg; i.p.; twice weekly for 7 doses; SCID mice with palpable RPMI8226 tumors) inhibits tumor growth in mice bearing human MM xenografts via FcγR-dependent mechanisms[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with palpable RPMI8226 tumors[1]
Dosage: 0.3, 3 and 9 mg/kg
Administration: Intraperitoneal injection; twice weekly for 7 doses
Result: Inhibited growth of established myeloma tumors in vivo and eradicates tumors in mice.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[XmAb 5592]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.51%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XmAb 55921221901-33-2XmAb5592XmAb-5592OthersFcFcγRIIIaFcγRIIa receptorantibody-dependent cellular cytotoxicityantibody dependent cellular phagocytosismultiple myeloma cellsInhibitorinhibitorinhibit

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