ZM600
ZM600 is a potent and orally active antihepatic fibrosis agent. ZM600 decreases the LPS (HY-D1056) induced protein expression of collagen I, α-SM, p-p65. ZM600 has the potential for the research of liver fibrosis.
For research use only. We do not sell to patients.
- Formula: C33H41FO3
- Molecular Weight:504.68
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
ZM600 shows cytotoxicity for LX-2 cells with an IC50 value of 38.17 µM[1].
ZM600 (0, 5, 10, 20 µM; 2+48 h) decreases the protein and mRNA expression of collagen I and α-SM induced by LPS (HY-D1056) and TGF-β1[1].
ZM600 (0, 5, 10, 20 µM; 2+2 h) decreases the LPS (HY-D1056) and TGF-β1 induced protein expression of p-p65, p-Smad2/3 and p-AKT in LX-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:LX-2 cells
-
Concentration:0, 5, 10, 20 µM
-
Incubation Time:2+48 h
-
Result:Suppressed LPS (1 µg/mL)-induced protein and mRNA expression of collagen I and α-SMA.
-
Cell Line:LX-2 cells
-
Concentration:0, 5, 10, 20 µM
-
Incubation Time:2+2 h
-
Result:Decreased the LPS-induced protein expression of p-p65, inhibits TGF-β1-induced phosphorylation of Smad2/3 and AKT in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:6-8 weeks, 18-20 g, Male C57BL/6J mice[1]
-
Dosage:15, 30 mg/kg
-
Administration:P.o.; daly from the fifth week until 8 weeks
-
Result:Inhibited the infiltration of inflammatory cells and reduced the edema and necrosis of hepatocytes, decreased the deposition of collagens in liver tissues, decreased positive areas of α-SMA in the livers.
Chemical Information
-
Molecular Weight 504.68
-
Formula C33H41FO3
-
SMILES
[H][C@@]12[C@]([H])([C@@]([H])(CC([C@@]2(CCCC(OC)=O)[H])C(C(C3=CC=C(C(F)=C3)C4=CC=CC=C4)C)=O)CCC5)C5CCC1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZM600 Related Classifications
HY-163778 Related Classifications
Powered by Bioz