5-Azidomethyl-2'-deoxyuridine
Based on 1 Customer Validation
5-Azidomethyl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog. 5-Azidomethyl-2'-deoxyuridine demonstrates effective radiosensitization in EMT6 tumor cells.. 5-Azidomethyl-2'-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- Reinheit: 99.76%
- CAS. Nr.: 59090-48-1
- Formel: C10H13N5O5
- Molecular Weight:283.24
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | ED50 |
90 μM
Compound: 10
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Compound tested for inhibition of the replication of L1210 cells in cell culture
Compound tested for inhibition of the replication of L1210 cells in cell culture
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[PMID: 6244411] |
Chemical Information
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CAS. Nr. 59090-48-1
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Appearance Solid
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Molecular Weight 283.24
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Formel C10H13N5O5
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Color White to off-white
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SMILES
O=C(C(CN=[N+]=[N-])=CN1[C@H]2C[C@H](O)[C@@H](CO)O2)NC1=O
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Synonyms
5-AmdU; α-Azidothymidine
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (176.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Wen Z, Peng J, Tuttle PR, et al. Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells. Org Lett. 2018;20(23):7400-7404. [Content Brief]
[2]. Adjei D, Reyes Y, Kumar A, et al. Pathways of the Dissociative Electron Attachment Observed in 5- and 6-Azidomethyluracil Nucleosides: Nitrogen (N2) Elimination vs Azide Anion (N3-) Elimination. J Phys Chem B. 2023;127(7):1563-1571. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5306 mL | 17.6529 mL | 35.3057 mL | 88.2644 mL |
| 5 mM | 0.7061 mL | 3.5306 mL | 7.0611 mL | 17.6529 mL | |
| 10 mM | 0.3531 mL | 1.7653 mL | 3.5306 mL | 8.8264 mL | |
| 15 mM | 0.2354 mL | 1.1769 mL | 2.3537 mL | 5.8843 mL | |
| 20 mM | 0.1765 mL | 0.8826 mL | 1.7653 mL | 4.4132 mL | |
| 25 mM | 0.1412 mL | 0.7061 mL | 1.4122 mL | 3.5306 mL | |
| 30 mM | 0.1177 mL | 0.5884 mL | 1.1769 mL | 2.9421 mL | |
| 40 mM | 0.0883 mL | 0.4413 mL | 0.8826 mL | 2.2066 mL | |
| 50 mM | 0.0706 mL | 0.3531 mL | 0.7061 mL | 1.7653 mL | |
| 60 mM | 0.0588 mL | 0.2942 mL | 0.5884 mL | 1.4711 mL | |
| 80 mM | 0.0441 mL | 0.2207 mL | 0.4413 mL | 1.1033 mL | |
| 100 mM | 0.0353 mL | 0.1765 mL | 0.3531 mL | 0.8826 mL |
5-Azidomethyl-2'-deoxyuridine Related Classifications
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