α-Casozepine
Based on 1 Customer Validation
α-Casozepine is an orally effective anxiolytic that binds to the benzodiazepine site of the GABAA receptor in bovine samples with an IC50 of 88 μM. α-Casozepine exerts anxiolytic and anti-stress effects on cats exposed to unfamiliar environments and dogs undergoing road transport. α-Casozepine exhibits significant anxiolytic activity in rats. α-Casozepine can be used in studies related to fear, anxiety and stress.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 117592-45-7
- Formula: C60H94N14O16
- Molecular Weight:1267.47
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Combined with cannabidiol (CBD) and L-Tryptophan (HY-N0623), α-Casozepine (21.2-32.1 mg/kg BW; p.o.; single administration) exerts mild anti-stress effects in dogs subjected to road transportation, as evidenced by a significantly smaller increase in post-stress serum cortisol levels compared with the placebo group[2].
α-Casozepine (0.4 mg/kg; i.p.; single administration) exhibits significant anxiolytic activity in the conditioned defensive burying paradigm of Wistar rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Domestic shorthair cats (5 neutered males, 7 spayed females, 7 intact females; age 4-12 years)[1]
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Dosage:Included in complete Royal Canin Feline Calm diet
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Administration:oral; twice daily; 4 weeks
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Result:Showed non-significant increase in distance traveled from baseline to test 1 and test 2, whereas control cats showed significant or marginally significant decreases.
Showed marginally not significant decrease in inactivity duration from baseline to test 1, and non-significant decrease from baseline to test 2.
Showed statistically significant increase in inactivity frequency from baseline to test 1, and non-significant increase from baseline to test 2.
Exhibited no significant changes in home room test or human interaction test compared to baseline.
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Animal Model:Norfolk Terrier, Beagle, Labrador Retriever (healthy adult, 3.6 years mean age, 3.6-36.0 kg weight range, 55.6% neutered male, 44.4% female [21 spayed, 3 entire])[2]
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Dosage:21.2-32.1 mg/kg BW (mean 24.2 mg/kg BW; co-administered with mean 1.8 mg/kg BW CBD and 14.3 mg/kg BW L-tryptophan)
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Administration:oral; single dose
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Result:Reduced serum cortisol increase from baseline to post-stress paradigm by a mean difference of -7.01 ng/mL compared to placebo.
Showed a non-significant trend for reduced lip licking compared to placebo.
Showed a non-significant trend for lower activity points compared to placebo.
Exerted no significant effects on heart rate, heart rate variability, body position, movement, whining, panting, or qualitative arousal ratings compared to placebo.
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Animal Model:Wistar rats[3]
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Dosage:0.4 mg/kg
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Administration:i.p.; single dose
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Result:Decreased the duration of probe burying compared to saline.
Reduced the ratio of retreats to approaches toward the probe.
Exerted effects comparable to those induced by 1 mg/kg diazepam.
Chemical Information
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CAS No. 117592-45-7
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Appearance Solid
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Molecular Weight 1267.47
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Formula C60H94N14O16
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Color White to off-white
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Sequence
Tyr-Leu-Gly-Tyr-Leu-Glu-Gln-Leu-Leu-Arg
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Sequence Shortening
YLGYLEQLLR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 66.67 mg/mL (52.60 mM; ultrasonic and adjust pH to 2 with 1 M HCl)
DMSO : 20 mg/mL (15.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Landsberg G, et al. Therapeutic effects of an alpha-casozepine and L-tryptophan supplemented diet on fear and anxiety in the cat. J Feline Med Surg. 2017;19(6):594-602. [Content Brief]
[2]. Flint HE, et al. Treats containing cannabidiol, L-tryptophan and α-casozepine have a mild stress-reducing effect in dogs. Front Vet Sci. 2025;12:1632868. Published 2025 Jul 29. [Content Brief]
[3]. Miclo L, et al. Characterization of alpha-casozepine, a tryptic peptide from bovine alpha(s1)-casein with benzodiazepine-like activity. FASEB J. 2001 Aug;15(10):1780-2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.7890 mL | 3.9449 mL | 7.8897 mL | 19.7243 mL |
| 5 mM | 0.1578 mL | 0.7890 mL | 1.5779 mL | 3.9449 mL | |
| 10 mM | 0.0789 mL | 0.3945 mL | 0.7890 mL | 1.9724 mL | |
| 15 mM | 0.0526 mL | 0.2630 mL | 0.5260 mL | 1.3150 mL | |
| H2O | 20 mM | 0.0394 mL | 0.1972 mL | 0.3945 mL | 0.9862 mL |
| 25 mM | 0.0316 mL | 0.1578 mL | 0.3156 mL | 0.7890 mL | |
| 30 mM | 0.0263 mL | 0.1315 mL | 0.2630 mL | 0.6575 mL | |
| 40 mM | 0.0197 mL | 0.0986 mL | 0.1972 mL | 0.4931 mL | |
| 50 mM | 0.0158 mL | 0.0789 mL | 0.1578 mL | 0.3945 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-Casozepine Related Classifications
HY-P2602 Related Classifications
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