α2A-AR agonist 1
Based on 1 Customer Validation
α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 2971825-58-6
- Formula: C12H11BrN2O
- Molecular Weight:279.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Adrenergic Receptor Isoforms
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Biological Activity
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Alpha-2A adrenergic receptor 0.23 nM (EC50) |
Alpha-1A adrenergic receptor 2.5 nM (EC50) |
Alpha-2B adrenergic receptor 16.3 nM (EC50) |
Alpha-2C adrenergic receptor 21.3 nM (EC50) |
Chemical Information
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CAS No. 2971825-58-6
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Appearance Solid
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Molecular Weight 279.13
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Formula C12H11BrN2O
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Color White to off-white
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SMILES
BrC1=C(C2=CC=C1)OCCC2C3=CNC=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 87.5 mg/mL (313.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5826 mL | 17.9128 mL | 35.8256 mL | 89.5640 mL |
| 5 mM | 0.7165 mL | 3.5826 mL | 7.1651 mL | 17.9128 mL | |
| 10 mM | 0.3583 mL | 1.7913 mL | 3.5826 mL | 8.9564 mL | |
| 15 mM | 0.2388 mL | 1.1942 mL | 2.3884 mL | 5.9709 mL | |
| 20 mM | 0.1791 mL | 0.8956 mL | 1.7913 mL | 4.4782 mL | |
| 25 mM | 0.1433 mL | 0.7165 mL | 1.4330 mL | 3.5826 mL | |
| 30 mM | 0.1194 mL | 0.5971 mL | 1.1942 mL | 2.9855 mL | |
| 40 mM | 0.0896 mL | 0.4478 mL | 0.8956 mL | 2.2391 mL | |
| 50 mM | 0.0717 mL | 0.3583 mL | 0.7165 mL | 1.7913 mL | |
| 60 mM | 0.0597 mL | 0.2985 mL | 0.5971 mL | 1.4927 mL | |
| 80 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1196 mL | |
| 100 mM | 0.0358 mL | 0.1791 mL | 0.3583 mL | 0.8956 mL |
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