Cat. No.: HY-N2848

Copy Link Print Information

α-Lapachone

Avis client

Based on 1 Customer Validation

α-Lapachone shows trypanocidal activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.51%
CAS No.: 4707-33-9
Formule: C₁₅H₁₄O₃
Masse moléculaire:242.27

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

α-Lapachone Chemical Structure

CAS No.: 4707-33-9

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

α-Lapachone shows trypanocidal activity^[1].

Voir tous les produits spécifiques à Isoform Parasite :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	GI₅₀	4 μM Compound: 29	Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
A549	CC₅₀	2.09 μM Compound: 29	Cytotoxicity against human A549 cells incubated for 24 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 24 hrs by MTT assay	[PMID: 33333397]
A549	GI₅₀	16.3 μM Compound: alpha-Lapachone	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 22819765]
A549	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human A549 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay Cytotoxicity against human A549 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay	[PMID: 32044231]
BC1 cell line	ED₅₀	6.7 μg/mL Compound: 7	Cytotoxicity against human BC1 cells Cytotoxicity against human BC1 cells	[PMID: 10785421]
BC1 cell line	IC₅₀	27.7 μM Compound: 5	Cytotoxicity against human BC1 cells after 72 hrs by SRB assay Cytotoxicity against human BC1 cells after 72 hrs by SRB assay	[PMID: 12088425]
Col2	ED₅₀	9.9 μg/mL Compound: 7	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 10785421]
Col2	IC₅₀	40.9 μM Compound: 5	Cytotoxicity against human Col2 cells after 72 hrs by SRB assay Cytotoxicity against human Col2 cells after 72 hrs by SRB assay	[PMID: 12088425]
HaCaT	IC₅₀	10 μM Compound: 3	Antiproliferative activity against human HaCaT cells Antiproliferative activity against human HaCaT cells	[PMID: 10479319]
HBL-100	GI₅₀	14 μM Compound: 1a, alpha-lapachone	Growth inhibition of human HBL100 cells by SRB assay Growth inhibition of human HBL100 cells by SRB assay	[PMID: 22560628]
HBL-100	GI₅₀	14 μM Compound: 29	Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
HCT-116	IC₅₀	19.11 μM Compound: alpha-Lapachone	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
HeLa	GI₅₀	15 μM Compound: 1a, alpha-lapachone	Growth inhibition of human HeLa cells by SRB assay Growth inhibition of human HeLa cells by SRB assay	[PMID: 22560628]
HeLa	GI₅₀	15 μM Compound: 29	Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
HeLa	GI₅₀	25 μM Compound: alpha-Lapachone	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 22819765]
HepG2	CC₅₀	2.09 μM Compound: 29	Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay	[PMID: 33333397]
HL-60	IC₅₀	13.46 μM Compound: 36	Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay	[PMID: 17249647]
HL-60	IC₅₀	8.18 μM Compound: alpha-Lapachone	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
Hs 683	GI₅₀	9 μM Compound: alpha-Lapachone	Antiproliferative activity against human Hs683 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human Hs683 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 22819765]
J774.A1	IC₅₀	285 μg/mL Compound: 12a	Cytotoxicity against mouse J774.A1 cells measured after 24 hrs by resazurin based assay Cytotoxicity against mouse J774.A1 cells measured after 24 hrs by resazurin based assay	[PMID: 31378595]
Jurkat	GI₅₀	75 μM Compound: alpha-Lapachone	Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 22819765]
K562	IC₅₀	>10 μM Compound: 2	Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay	[PMID: 30003778]
KB	ED₅₀	13 μg/mL Compound: 7	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 10785421]
KB	IC₅₀	53.7 μM Compound: 5	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 12088425]
KB-V1	IC₅₀	34.3 μM Compound: 5	Cytotoxicity against human KBV1 cells after 72 hrs by SRB assay Cytotoxicity against human KBV1 cells after 72 hrs by SRB assay	[PMID: 12088425]
LLC-PK1	CC₅₀	2.09 μM Compound: 29	Cytotoxicity against human LLC-PK1 cells incubated for 24 hrs by MTT assay Cytotoxicity against human LLC-PK1 cells incubated for 24 hrs by MTT assay	[PMID: 33333397]
LNCaP	ED₅₀	7.1 μg/mL Compound: 7	Cytotoxicity against human LNCaP cells Cytotoxicity against human LNCaP cells	[PMID: 10785421]
LNCaP	IC₅₀	29.3 μM Compound: 5	Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay	[PMID: 12088425]
LoVo	GI₅₀	24.4 μM Compound: alpha-Lapachone	Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 22819765]
Lu1	IC₅₀	21.9 μM Compound: 5	Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay	[PMID: 12088425]
M109	ED₅₀	9 μg/mL Compound: 7	Cytotoxicity against human M109 cells Cytotoxicity against human M109 cells	[PMID: 10785421]
MCF7	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay	[PMID: 32044231]
MCF7	IC₅₀	38 μM Compound: 5	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 12088425]
MDA-MB-231	IC₅₀	>10 μM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay	[PMID: 30003778]
MDA-MB-231	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay	[PMID: 32044231]
MRC5	CC₅₀	2.09 μM Compound: 29	Cytotoxicity against human MRC5 cells incubated for 24 hrs by MTT assay Cytotoxicity against human MRC5 cells incubated for 24 hrs by MTT assay	[PMID: 33333397]
MRC5	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 48 hrs by alamar blue assay Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 48 hrs by alamar blue assay	[PMID: 26638044]
OVCAR-8	IC₅₀	14.79 μM Compound: alpha-Lapachone	Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
P388	IC₅₀	0.8 μM Compound: 5	Cytotoxicity against mouse P388 cells after 72 hrs by SRB assay Cytotoxicity against mouse P388 cells after 72 hrs by SRB assay	[PMID: 12088425]
PBMC	IC₅₀	>20.66 μM Compound: alpha-Lapachone	Cytotoxicity against human PBMC cells after 72 hrs by MTT assay Cytotoxicity against human PBMC cells after 72 hrs by MTT assay	10.1039/C4MD00371C
PC-3	GI₅₀	13 μM Compound: alpha-Lapachone	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 22819765]
Peritoneal macrophage cell	CC₅₀	3.8 μM Compound: 17	Cytotoxicity against Swiss mouse peritoneal macrophages after 24 hrs by MTT assay Cytotoxicity against Swiss mouse peritoneal macrophages after 24 hrs by MTT assay	[PMID: 23535320]
SF-295	IC₅₀	18.77 μM Compound: alpha-Lapachone	Cytotoxicity against human SF295 cells after 72 hrs by MTT assay Cytotoxicity against human SF295 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
SK-MEL-2	IC₅₀	7.9 μM Compound: 5	Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay	[PMID: 12088425]
SK-MEL-28	GI₅₀	4.7 μM Compound: alpha-Lapachone	Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 22819765]
SK-N-SH	ED₅₀	5.1 μg/mL Compound: 7	Cytotoxicity against human SK-N-SH cells Cytotoxicity against human SK-N-SH cells	[PMID: 10785421]
SW1573	GI₅₀	3.1 μM Compound: 1a, alpha-lapachone	Growth inhibition of human SW1573 cells by SRB assay Growth inhibition of human SW1573 cells by SRB assay	[PMID: 22560628]
SW1573	GI₅₀	3.1 μM Compound: 29	Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
SW626	ED₅₀	3 μg/mL Compound: 7	Cytotoxicity against human SW626 cells Cytotoxicity against human SW626 cells	[PMID: 10785421]
SW626	IC₅₀	12.4 μM Compound: 5	Cytotoxicity against human SW626 cells after 72 hrs by SRB assay Cytotoxicity against human SW626 cells after 72 hrs by SRB assay	[PMID: 12088425]
T47D	GI₅₀	25 μM Compound: 29	Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]
U-373MG ATCC	GI₅₀	23.1 μM Compound: alpha-Lapachone	Antiproliferative activity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 22819765]
Vero	CC₅₀	1.2 μM Compound: 9	Cytotoxicity against african green monkey Vero cells after 72 hrs by spectrophotometric analysis Cytotoxicity against african green monkey Vero cells after 72 hrs by spectrophotometric analysis	[PMID: 22795899]
WiDr	GI₅₀	26 μM Compound: 1a, alpha-lapachone	Growth inhibition of human WiDr cells by SRB assay Growth inhibition of human WiDr cells by SRB assay	[PMID: 22560628]
WiDr	GI₅₀	26 μM Compound: 29	Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay	[PMID: 20304655]

Chemical Information

CAS No. 4707-33-9
Appearance Solid
Masse moléculaire 242.27
Formule C₁₅H₁₄O₃
Color Light brown to brown
SMILES

O=C(C1=C2OC(C)(C)CC1)C3=C(C2=O)C=CC=C3
Structure Classification
- Quinones
- Naphthalene Quinones
Initial Source
- Plants
- Compositae
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (412.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1276 mL

20.6381 mL

41.2763 mL

5 mM

0.8255 mL

4.1276 mL

8.2553 mL

10 mM

0.4128 mL

2.0638 mL

4.1276 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pinto AV, de Castro SL. The trypanocidal activity of naphthoquinones: a review. Molecules. 2009;14(11):4570-4590. Published 2009 Nov 10. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1276 mL	20.6381 mL	41.2763 mL	103.1907 mL
	5 mM	0.8255 mL	4.1276 mL	8.2553 mL	20.6381 mL
	10 mM	0.4128 mL	2.0638 mL	4.1276 mL	10.3191 mL
	15 mM	0.2752 mL	1.3759 mL	2.7518 mL	6.8794 mL
	20 mM	0.2064 mL	1.0319 mL	2.0638 mL	5.1595 mL
	25 mM	0.1651 mL	0.8255 mL	1.6511 mL	4.1276 mL
	30 mM	0.1376 mL	0.6879 mL	1.3759 mL	3.4397 mL
	40 mM	0.1032 mL	0.5160 mL	1.0319 mL	2.5798 mL
	50 mM	0.0826 mL	0.4128 mL	0.8255 mL	2.0638 mL
	60 mM	0.0688 mL	0.3440 mL	0.6879 mL	1.7198 mL
	80 mM	0.0516 mL	0.2580 mL	0.5160 mL	1.2899 mL
	100 mM	0.0413 mL	0.2064 mL	0.4128 mL	1.0319 mL

Keywords

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

α-Lapachone

Anti-Infection Compound Library

Natural Product Library

Covalent Screening Library

Traditional Chinese Medicine Active Compound Library

Antiparasitic Compound library

Plant-Sourced Natural Product Library

Bioactive Compound Library Max

Covalent Screening Library Plus

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Quinones Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

α-Lapachone

Anti-Infection Compound Library

Natural Product Library

Covalent Screening Library

Traditional Chinese Medicine Active Compound Library

Antiparasitic Compound library

Plant-Sourced Natural Product Library

Bioactive Compound Library Max

Covalent Screening Library Plus

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Quinones Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

α-Lapachone Related Classifications

HY-N2848 Related Classifications