1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. DNA/RNA Synthesis
    ADC Cytotoxin
  3. ε-Amanitin

ε-Amanitin 

Cat. No.: HY-131083
Handling Instructions

ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II.

For research use only. We do not sell to patients.

ε-Amanitin Chemical Structure

ε-Amanitin Chemical Structure

CAS No. : 21705-02-2

Size Price Stock
1 mg USD 1550 Ask For Quote & Lead Time
5 mg USD 5550 Ask For Quote & Lead Time
10 mg USD 8750 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

In Vitro

Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

903.96

Formula

C₃₉H₅₃N₉O₁₄S

CAS No.

21705-02-2

SMILES

O=[S](C[[email protected]](NC(CNC1=O)=O)C(N[[email protected]](C2=O)CC(O)=O)=O)C(N3)=C(C[[email protected]@H](C(NCC(N[[email protected]]1[[email protected]@H](C)CC)=O)=O)NC([[email protected]@H](NC([[email protected]](C4)N2C[[email protected]@H]4O)=O)[[email protected]@H](C)[[email protected]@H](O)C)=O)C(C3=C5)=CC=C5O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ε-AmanitinDNA/RNA SynthesisADC CytotoxinsynthesismRNAbiosynthesiscellularapoptosiscyclicpeptideInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ε-Amanitin
Cat. No.:
HY-131083
Quantity:
MCE Japan Authorized Agent: