1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. DNA/RNA Synthesis
    ADC Cytotoxin
  3. ε-Amanitin

ε-Amanitin 

Cat. No.: HY-131083
Handling Instructions

ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II.

For research use only. We do not sell to patients.

ε-Amanitin Chemical Structure

ε-Amanitin Chemical Structure

CAS No. : 21705-02-2

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Description

ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

In Vitro

Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation[1].

Molecular Weight

903.96

Formula

C₃₉H₅₃N₉O₁₄S

CAS No.

21705-02-2

SMILES

O=[S](C[[email protected]](NC(CNC1=O)=O)C(N[[email protected]](C2=O)CC(O)=O)=O)C(N3)=C(C[[email protected]@H](C(NCC(N[[email protected]]1[[email protected]@H](C)CC)=O)=O)NC([[email protected]@H](NC([[email protected]](C4)N2C[[email protected]@H]4O)=O)[[email protected]@H](C)[[email protected]@H](O)C)=O)C(C3=C5)=CC=C5O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ε-AmanitinDNA/RNA SynthesisADC CytotoxinsynthesismRNAbiosynthesiscellularapoptosiscyclicpeptideInhibitorinhibitorinhibit

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