2,2,2-TEMPS
2,2,2-TEMPS is a mGlu2 receptor positive allosteric modulator (EC50 = 14 nM). 2,2,2-TEMPS can be used in research on psychiatric disorders.
For research use only. We do not sell to patients.
- CAS No.: 353234-67-0
- Formula: C19H23F3N2O3S
- Molecular Weight:416.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
mGluR2 14 nM (EC50) |
In Vitro
2,2,2-TEMPS is a potent mGlu2 receptor positive allosteric modulator with an EC50 of 14 nM in the FLIPR assay[1].
2,2,2-TEMPS acts as an mGlu2 receptor PAM by binding to an allosteric site within transmembrane regions IV/V[1].
2,2,2-TEMPS (increasing concentrations) increases the specific binding of 3[H]-LY354740 at the orthosteric site of rat mGlu2 in CHO mGlu2 membranes with an EC50 of 9.1 nM[2].
3[H]-2,2,2-TEMPS (3 nM; 1 h) binds to the allosteric site of rat mGlu2 in CHO mGlu2 membranes with a Kd of 4.2 nM and is displaced by unlabeled 2,2,2-TEMPS with an IC50 of 5.5 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 353234-67-0
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Molecular Weight 416.46
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Formula C19H23F3N2O3S
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SMILES
O=S(N(CC1=CC=CN=C1)C2=CC(OC(CCC)C)=CC=C2)(CC(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2,2,2-TEMPS Related Classifications
HY-189111 Related Classifications
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