2',3'-Cyclic NADP disodium
2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.
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- CAS No.: 100929-77-9
- Formula: C21H24N7Na2O16P3
- Molecular Weight:769.35
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Storage:
-80°C
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 100929-77-9
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Appearance Solid
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Molecular Weight 769.35
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Formula C21H24N7Na2O16P3
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Color White to off-white
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SMILES
O=[P](O[P](OC[C@H]([C@H]1O)O[C@]([N+]2=CC=CC(C(N)=O)=C2)([H])[C@@H]1O)([O-])=O)(O[Na])OC[C@H]3O[C@](N4C5=NC=NC(N)=C5N=C4)([H])[C@@](O6)([H])[C@]3([H])O[P]6(O[Na])=O
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Synonyms
2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate
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Shipping
Shipping with dry ice.
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Storage
-80°C
Protocols
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Calcium Spark Assay
Calcium sparks are localized, transient increases in intracellular calcium concentration ([Ca2+]i) that occur in cardiac myocytes and represent elementary events underlying excitation-contraction coupling. These events are generated by the coordinated opening of clusters of ryanodine receptors (RyRs) on the sarcoplasmic reticulum membrane, leading to a brief release of Ca2+ into the cytosol. The detection and analysis of calcium sparks provide insights into the mechanisms of calcium handling and signaling in cardiac cells. Imaging techniques using fluorescent calcium indicators such as Fluo-3 are employed to visualize these subcellular calcium transients with high spatial and temporal resolution. The protocol is based on established methodologies described in primary literature for both experimental measurement and automated analysis of calcium sparks.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2',3'-Cyclic NADP disodium Related Classifications
HY-137672A Related Classifications
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