2-Amino-2'-deoxyadenosine
Based on 1 Customer Validation
2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 4546-70-7
- Formula: C10H14N6O3
- Molecular Weight:266.26
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-HSB-2 | IC50 |
1.7 μg/mL
Compound: araDAP
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Antiproliferative effects on CCRF-HSB-2 (human leukemia) cells.
Antiproliferative effects on CCRF-HSB-2 (human leukemia) cells.
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[PMID: 9216836] |
| HEL | ED50 |
>100 μg/mL
Compound: araDAP
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Antiviral activity against herpes simplex virus-2 (HSV-2) Ms strain in HEL (human erythroleukemia) cells.
Antiviral activity against herpes simplex virus-2 (HSV-2) Ms strain in HEL (human erythroleukemia) cells.
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[PMID: 9216836] |
| HEL | ED50 |
12.9 μg/mL
Compound: araDAP
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Antiviral activity against human cytomegalovirus (HCMV) AD 169 strain HEL (human erythroleukemia) cells.
Antiviral activity against human cytomegalovirus (HCMV) AD 169 strain HEL (human erythroleukemia) cells.
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[PMID: 9216836] |
| HEL | ED50 |
49 μg/mL
Compound: araDAP
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Antiviral activity against herpes simplex virus-1 VR-3 strain in HEL (human erythroleukemia) cells.
Antiviral activity against herpes simplex virus-1 VR-3 strain in HEL (human erythroleukemia) cells.
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[PMID: 9216836] |
| HEL | ED50 |
9.2 μg/mL
Compound: araDAP
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Antiviral activity against varicella zoster virus (VZV) Oka strain in HEL (human erythroleukemia) cells.
Antiviral activity against varicella zoster virus (VZV) Oka strain in HEL (human erythroleukemia) cells.
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[PMID: 9216836] |
| MT4 | ED50 |
>125 μM
Compound: 11b
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Dose required to inhibit cytopathic effect of human immunodeficiency virus replication in MT-4 cells.
Dose required to inhibit cytopathic effect of human immunodeficiency virus replication in MT-4 cells.
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[PMID: 3172142] |
2-Amino-2'-deoxyadenosine is a purine nucleoside analog, and studies on its synthesis and modification are of critical significance in the development of anti-tumor and antibacterial drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4546-70-7
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Appearance Solid
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Molecular Weight 266.26
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Formula C10H14N6O3
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Color White to off-white
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SMILES
OC[C@@H]1[C@@H](O)C[C@H](N2C=NC3=C2N=C(N)N=C3N)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (375.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7557 mL | 18.7786 mL | 37.5573 mL | 93.8932 mL |
| 5 mM | 0.7511 mL | 3.7557 mL | 7.5115 mL | 18.7786 mL | |
| 10 mM | 0.3756 mL | 1.8779 mL | 3.7557 mL | 9.3893 mL | |
| 15 mM | 0.2504 mL | 1.2519 mL | 2.5038 mL | 6.2595 mL | |
| 20 mM | 0.1878 mL | 0.9389 mL | 1.8779 mL | 4.6947 mL | |
| 25 mM | 0.1502 mL | 0.7511 mL | 1.5023 mL | 3.7557 mL | |
| 30 mM | 0.1252 mL | 0.6260 mL | 1.2519 mL | 3.1298 mL | |
| 40 mM | 0.0939 mL | 0.4695 mL | 0.9389 mL | 2.3473 mL | |
| 50 mM | 0.0751 mL | 0.3756 mL | 0.7511 mL | 1.8779 mL | |
| 60 mM | 0.0626 mL | 0.3130 mL | 0.6260 mL | 1.5649 mL | |
| 80 mM | 0.0469 mL | 0.2347 mL | 0.4695 mL | 1.1737 mL | |
| 100 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.9389 mL |
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