2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2-Methyl estradiol

2-Methyl estradiol, an endogenous metabolite of Estradiol (HY-B0141), inhibits cell proliferation and angiogenesis, with IC50 values of 3 and 2.39 μM for HUVEC and MCF-7 human breast cancer cell proliferation, respectively.

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2-Methyl estradiol

2-Methyl estradiol Chemical Structure

CAS No. : 1818-12-8

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2-Methyl estradiol Related Antibodies

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Description

2-Methyl estradiol, an endogenous metabolite of Estradiol (HY-B0141), inhibits cell proliferation and angiogenesis, with IC50 values of 3 and 2.39 μM for HUVEC and MCF-7 human breast cancer cell proliferation, respectively[1].
Cellular Effect
Cell Line Type Value Description References
DU-145 GI50
16 μM
Compound: 9
Cytotoxicity against prostate DU-145 cancer cell lines.
Cytotoxicity against prostate DU-145 cancer cell lines.
[PMID: 7783135]
DU-145 GI50
51 μM
Compound: 8
Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay
Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay
[PMID: 17696419]
HCT-116 GI50
3.6 μM
Compound: 9
Cytotoxicity against colon HCT116 cancer cell lines.
Cytotoxicity against colon HCT116 cancer cell lines.
[PMID: 7783135]
HOP-62 GI50
11 μM
Compound: 9
Cytotoxicity against lung HOP-62 cancer cell lines.
Cytotoxicity against lung HOP-62 cancer cell lines.
[PMID: 7783135]
MDA-MB-435 GI50
1.8 μM
Compound: 9
Cytotoxicity against breast MDA-MB-435 cancer cell lines.
Cytotoxicity against breast MDA-MB-435 cancer cell lines.
[PMID: 7783135]
OVCAR-3 GI50
9.1 μM
Compound: 9
Cytotoxicity against ovarian OVCAR-3 cancer cell lines.
Cytotoxicity against ovarian OVCAR-3 cancer cell lines.
[PMID: 7783135]
Panel (Carcinoma cell lines) GI50
8.1 μM
Compound: 9
Mean graph midpoint for all human cancer cell line cytotoxicity.
Mean graph midpoint for all human cancer cell line cytotoxicity.
[PMID: 7783135]
SF-539 GI50
7.4 μM
Compound: 9
Cytotoxicity against CNS SF-539 cancer cell lines.
Cytotoxicity against CNS SF-539 cancer cell lines.
[PMID: 7783135]
SN12C GI50
17 μM
Compound: 9
Cytotoxicity against renal SN12C cancer cell lines.
Cytotoxicity against renal SN12C cancer cell lines.
[PMID: 7783135]
UACC-62 GI50
5.4 μM
Compound: 9
Cytotoxicity against melanoma UACC-62 cancer cell lines.
Cytotoxicity against melanoma UACC-62 cancer cell lines.
[PMID: 7783135]
Molecular Weight

286.41

Formula

C19H26O2
CAS No.
SMILES

C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(C)=C(O)C=C4CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-Methyl estradiol Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Methyl estradiol1818-12-8Endogenous MetaboliteHUVECMCF-7EstradiolInhibitorinhibitorinhibit

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2-Methyl estradiol
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HY-W702106
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