2. Apoptosis
  3. Apoptosis Caspase IAP Survivin
  4. (2''S)-2'',3''-Dihydrodelicaflavone

(2''S)-2'',3''-Dihydrodelicaflavone is a biflavonoid compound present in the whole herb of Selaginella doederleinii, which exhibits antiproliferative and apoptosis-inducing activities against non-small cell lung cancer cells. (2''S)-2'',3''-Dihydrodelicaflavone can be used in the research of non-small cell lung cancer.

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(2''S)-2'',3''-Dihydrodelicaflavone

(2''S)-2'',3''-Dihydrodelicaflavone Chemical Structure

CAS No. : 3035699-17-0

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(2''S)-2'',3''-Dihydrodelicaflavone Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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cIAP cIAP-1 cIAP-2 XIAP

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Description

(2''S)-2'',3''-Dihydrodelicaflavone is a biflavonoid compound present in the whole herb of Selaginella doederleinii, which exhibits antiproliferative and apoptosis-inducing activities against non-small cell lung cancer cells. (2''S)-2'',3''-Dihydrodelicaflavone can be used in the research of non-small cell lung cancer[1].

IC50 & Target[1]

Caspase 3

 

XIAP

 

In Vitro

(2''S)-2'',3''-Dihydrodelicaflavone (compound 1) (0-100 μM; 24 h) potently inhibits the proliferation of A549 and H1299 non-small cell lung cancer (NSCLC) cells, with IC50 values of 3.1 μM and 7.3 μM, respectively, and exhibits low cytotoxicity toward non-cancerous MRC-5 cells[1].
(2''S)-2'',3''-Dihydrodelicaflavone (3 μM; 24 h) induces apoptosis in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(2''S)-2'',3''-Dihydrodelicaflavone Related Antibodies

Apoptosis Analysis[1]

Cell Line: human NSCLC A549 cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Induced morphological changes indicative of apoptosis, including cell shrinkage, detachment, and reduced live cell numbers, with a significant reduction in the percentage of live cells compared to the control group.
Induced an apoptosis incidence of 41.3% in A549 cells.

Western Blot Analysis[1]

Cell Line: human NSCLC A549 cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Increased the relative levels of caspase-3 and cleaved caspase-3.
Reduced the relative levels of anti-apoptotic proteins XIAP and survivin.
Molecular Weight

540.47

Formula

C30H20O10
CAS No.
SMILES

O=C(C(OC1=CC=C([C@H]2OC3=CC(O)=CC(O)=C3C(C2)=O)C=C1)=C(C4=CC=C(C=C4)O)OC5=CC(O)=C6)C5=C6O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(2''S)-2'',3''-Dihydrodelicaflavone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(2''S)-2'',3''-Dihydrodelicaflavone3035699-17-0ApoptosisCaspaseIAPSurvivinA549 cellsnon-small cell lung cancer cellsXIAPcaspase-3Selaginella doederleiniiapoptosiscleaved-caspase-3survivinH1299 NSCLC cellsMRC-5 cellsInhibitorinhibitorinhibit

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(2''S)-2'',3''-Dihydrodelicaflavone
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