(2''S)-2'',3''-Dihydrodelicaflavone
(2''S)-2'',3''-Dihydrodelicaflavone is a biflavonoid compound present in the whole herb of Selaginella doederleinii, which exhibits antiproliferative and apoptosis-inducing activities against non-small cell lung cancer cells. (2''S)-2'',3''-Dihydrodelicaflavone can be used in the research of non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 3035699-17-0
- Formula: C30H20O10
- Molecular Weight:540.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Biological Activity
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Caspase 3 |
XIAP |
(2''S)-2'',3''-Dihydrodelicaflavone (compound 1) (0-100 μM; 24 h) potently inhibits the proliferation of A549 and H1299 non-small cell lung cancer (NSCLC) cells, with IC50 values of 3.1 μM and 7.3 μM, respectively, and exhibits low cytotoxicity toward non-cancerous MRC-5 cells[1].
(2''S)-2'',3''-Dihydrodelicaflavone (3 μM; 24 h) induces apoptosis in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human NSCLC A549 cells
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Concentration:3 μM
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Incubation Time:24 h
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Result:Induced morphological changes indicative of apoptosis, including cell shrinkage, detachment, and reduced live cell numbers, with a significant reduction in the percentage of live cells compared to the control group.
Induced an apoptosis incidence of 41.3% in A549 cells.
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Cell Line:human NSCLC A549 cells
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Concentration:3 μM
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Incubation Time:24 h
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Result:Increased the relative levels of caspase-3 and cleaved caspase-3.
Reduced the relative levels of anti-apoptotic proteins XIAP and survivin.
Chemical Information
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CAS No. 3035699-17-0
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Molecular Weight 540.47
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Formula C30H20O10
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SMILES
O=C(C(OC1=CC=C([C@H]2OC3=CC(O)=CC(O)=C3C(C2)=O)C=C1)=C(C4=CC=C(C=C4)O)OC5=CC(O)=C6)C5=C6O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(2''S)-2'',3''-Dihydrodelicaflavone Related Classifications
HY-N18315 Related Classifications
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