1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

5-HT4 antagonist 1 

Cat. No.: HY-100170
Handling Instructions

5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.

For research use only. We do not sell to patients.

5-HT4 antagonist 1 Chemical Structure

5-HT4 antagonist 1 Chemical Structure

CAS No. : 261766-73-8

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.

IC50 & Target

pKI: 9.6 (5-HT4 receptor)[1]

In Vitro

5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.

In Vivo

5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h[1].

References
Molecular Weight

480.62

Formula

C₂₃H₃₆N₄O₅S

CAS No.

261766-73-8

SMILES

O=C(C1=C2OCCOC2=CC=C1)NCC3CCN(CCCS(=O)(N4CCN(C)CC4)=O)CC3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
5-HT4 antagonist 1
Cat. No.:
HY-100170
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5-HT4 antagonist 1

Cat. No.: HY-100170