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Cat. No.: HY-187851

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5-Oxo-15-HETE

5-Oxo-15-HETE is a derivative of 5-Oxo-ETE (HY-112549). 5-Oxo-15-HETE is generated from 5-Oxo-ETE by 15-LO. 5-Oxo-15-HETE is approximately eight times less potent than 5-Oxo-ETE in inducing Ca²⁺ mobilization. 5-Oxo-15-HETE exhibits chemotactic activity.

For research use only. We do not sell to patients.

CAS No.: 142828-12-4
Formula: C₂₀H₃₀O₄
Molecular Weight:334.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

5-Oxo-15-HETE Chemical Structure

CAS No.: 142828-12-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

15-LOX

All Lipoxygenase Isoforms :

All Calcium Channel Isoforms :

In Vitro

5-Oxo-15-HETE exhibits chemotactic activity in isolated human polymorphonuclear leukocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 142828-12-4
Molecular Weight 334.45
Formula C₂₀H₃₀O₄
SMILES

CCCCC[C@H](O)/C=C/C=C\C/C=C\C=C\C(CCCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kühn H. Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)XY-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)XY-9Z,11E-octadecadienoic acid. Prog Lipid Res. 1996 Sep;35(3):203-26.

[2]. Patel P, et al. 5-oxo-15-HETE: total synthesis and bioactivity. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1857-60.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols
Purity & Documentation
References

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5-Oxo-15-HETE

All Lipoxygenase Isoforms

All Calcium Channel Isoforms