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Cat. No.: HY-187851

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5-Oxo-15-HETE

5-Oxo-15-HETE is a derivative of 5-Oxo-ETE (HY-112549). 5-Oxo-15-HETE is generated from 5-Oxo-ETE by 15-LO. 5-Oxo-15-HETE is approximately eight times less potent than 5-Oxo-ETE in inducing Ca²⁺ mobilization. 5-Oxo-15-HETE exhibits chemotactic activity.

For research use only. We do not sell to patients.

CAS No.: 142828-12-4
Formula: C₂₀H₃₀O₄
Molecular Weight:334.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

5-Oxo-15-HETE Chemical Structure

CAS No.: 142828-12-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
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Biological Activity

Description

IC₅₀ & Target

^[1]

15-LOX

All Lipoxygenase Isoforms :

All Calcium Channel Isoforms :

In Vitro

5-Oxo-15-HETE exhibits chemotactic activity in isolated human polymorphonuclear leukocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Ca²⁺ Staining Technique

Chemical Information

CAS No. 142828-12-4
Molecular Weight 334.45
Formula C₂₀H₃₀O₄
SMILES

CCCCC[C@H](O)/C=C/C=C\C/C=C\C=C\C(CCCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kühn H. Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)XY-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)XY-9Z,11E-octadecadienoic acid. Prog Lipid Res. 1996 Sep;35(3):203-26.

[2]. Patel P, et al. 5-oxo-15-HETE: total synthesis and bioactivity. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1857-60.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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5-Oxo-15-HETE

All Lipoxygenase Isoforms

All Calcium Channel Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

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5-Oxo-15-HETE Related Classifications

HY-187851 Related Classifications

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