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製品番号: HY-153269

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9-Methyl-SMN-C5

9-Methyl-SMN-C5 is a SMN2 pre-mRNA splicing modifier that corrects exon 7 splicing. 9-Methyl-SMN-C5 binds to ESE2 and the 5'-splice site of exon 7, and stabilizes the RNP complex. 9-Methyl-SMN-C5 induces chemical shift perturbations at the 5'-splice site of the exon 7-U1 snRNA duplex. 9-Methyl-SMN-C5 partially blocks the binding of hnRNP G to ESE2. 9-Methyl-SMN-C5 can be used for research on spinal muscular atrophy (SMA).

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CAS 番号: 2248691-80-5
分子式: C₂₂H₂₃FN₆O
分子量:406.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

9-Methyl-SMN-C5 構造式

CAS 番号: 2248691-80-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

9-Methyl-SMN-C5 binds the 5′-ss exon 7-U1 snRNA duplex as well as the ESE2 fragment of SMN2 pre-mRNA, with the 5′-ss interaction being more important than ESE2^[1].
9-Methyl-SMN-C5 corrects exon 7 splicing of SMN2 pre-mRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

RNA extraction experimental

化学情報

CAS 番号 2248691-80-5
分子量 406.47
分子式 C₂₂H₂₃FN₆O
SMILES

O=C1C=C(N=C2C(=CC(=CN12)N3CCN(C)CC3)C)C=4C=C(F)C5=NC(=CN5C4)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wang J, et al. Mechanistic studies of a small-molecule modulator of SMN2 splicing. Proceedings of the National Academy of Sciences of the United States of America. 2018 May 15;115(20):E4604-E4612. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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