Aldicarb sulfone
Based on 1 Customer Validation
Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase.
For research use only. We do not sell to patients.
- Purity: 99.46%
- CAS No.: 1646-88-4
- Formula: C7H14N2O4S
- Molecular Weight:222.26
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Aldicarb sulfone (19.2 ppm; drinking water) in combination with Aldicarb sulfoxide (HY-124104) decreases plasma pseudocholinesterase levels to 23%-32% of normal and red blood cell cholinesterase to 37%-43% of normal in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tylenchulus semipenetrans (citrus nematode; eggs, larvae, and adult males/females isolated from citrus roots)[1]
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Dosage:1, 10, 50 and 100 μg/mL in distilled water
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Administration:Eggs or larvae were incubated in chemical solutions for 18 days (egg hatch assay) or 48 hours (motility assay), with daily solution replacement for egg experiments
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Result:Significantly inhibited egg hatch by 15-17% compared to control, with delayed embryonic development and reduced larval movement within eggs at 50 and 100 μg/mL.
Reduced nematode motility by 33-45% at 50 and 100 μg/mL, while 1 and 10 μg/mL showed no significant effect.
Retarded male larval development to adulthood at 10 μg/mL (adult percentage reduced from 39% to 17%) and almost completely inhibited at 50-100 μg/mL, with morphological abnormalities (e.g., body wrinkling, swelling).
Chemical Information
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CAS No. 1646-88-4
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Appearance Solid
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Molecular Weight 222.26
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Formula C7H14N2O4S
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Color White to off-white
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SMILES
CC(S(=O)(C)=O)(C)/C=N/OC(NC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 31.25 mg/mL (140.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.25 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.25 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4992 mL | 22.4962 mL | 44.9924 mL | 112.4809 mL |
| 5 mM | 0.8998 mL | 4.4992 mL | 8.9985 mL | 22.4962 mL | |
| 10 mM | 0.4499 mL | 2.2496 mL | 4.4992 mL | 11.2481 mL | |
| 15 mM | 0.2999 mL | 1.4997 mL | 2.9995 mL | 7.4987 mL | |
| 20 mM | 0.2250 mL | 1.1248 mL | 2.2496 mL | 5.6240 mL | |
| 25 mM | 0.1800 mL | 0.8998 mL | 1.7997 mL | 4.4992 mL | |
| 30 mM | 0.1500 mL | 0.7499 mL | 1.4997 mL | 3.7494 mL | |
| 40 mM | 0.1125 mL | 0.5624 mL | 1.1248 mL | 2.8120 mL | |
| 50 mM | 0.0900 mL | 0.4499 mL | 0.8998 mL | 2.2496 mL | |
| 60 mM | 0.0750 mL | 0.3749 mL | 0.7499 mL | 1.8747 mL | |
| 80 mM | 0.0562 mL | 0.2812 mL | 0.5624 mL | 1.4060 mL | |
| 100 mM | 0.0450 mL | 0.2250 mL | 0.4499 mL | 1.1248 mL |
Aldicarb sulfone Related Classifications
HY-17530 Related Classifications
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