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Fluzinamide is an effective antiepileptic.

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Fluzinamide Chemical Structure

Fluzinamide Chemical Structure

CAS No. : 76263-13-3

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Description

Fluzinamide is an effective antiepileptic.

In Vivo

Fluzinamide, an antiepileptic agent effective against partial seizures, is metabolized extensively in mice, rats and dogs[1].The anticonvulsant properties of Fluzinamide (AHR-8559) are evaluated in the kindled amygdaloid seizure model in rats. Fluzinamide significantly attenuates afterdischarge durations and the severity of the accompanying convulsive responses in previously kindled rats at doses that does not cause sedation or ataxia. After acute intraperitoneal injections, the maximum anticonvulsant effectiveness against suprathreshold (400 μA) stimulation is seen at 30 min. Fluzinamide (10-80 mg/kg i.p.) is also evaluated in kindled rats using threshold (20 μA increments) seizures. Low doses of Fluzinamide significantly elevate seizure threshold and reduce both elicited after discharge durations and seizure severity. When administered daily during kindling acquisition, Fluzinamide (20 and 40 mg/kg i.p.) significantly increases the number of trials necessary to complete kindling. The duration and the severity of the responses induced by stimulations during the acquisition period are reduced[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

274.24

Formula

C12H13F3N2O2

CAS No.
SMILES

O=C(N1CC(OC2=CC=CC(C(F)(F)F)=C2)C1)NC

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Fluzinamide
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HY-101802
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