1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. GCN2-IN-1

GCN2-IN-1 (Synonyms: A-92)

Cat. No.: HY-100877 Purity: >98.0%
Handling Instructions

GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay.

For research use only. We do not sell to patients.

GCN2-IN-1 Chemical Structure

GCN2-IN-1 Chemical Structure

CAS No. : 1448693-69-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
25 mg USD 580 In-stock
Estimated Time of Arrival: December 31
50 mg USD 980 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1780 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay.

IC50 & Target

IC50: <0.3 μM (GCN2)[1]

In Vitro

GCN2-IN-1 (Compound A-92) is a GCN2 inhibitor, which may be useful as a chemotherapeutic drug for the treatment of cancer[1].

Molecular Weight

402.41

Formula

C₁₉H₁₈N₁₀O

CAS No.

1448693-69-3

SMILES

C1(NC2=CN(C3CCOCC3)N=C2)=NC=C(N=NN4C5=CC6=C(C=C5)C=NN6)C4=N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (149.10 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4850 mL 12.4251 mL 24.8503 mL
5 mM 0.4970 mL 2.4850 mL 4.9701 mL
10 mM 0.2485 mL 1.2425 mL 2.4850 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
GCN2-IN-1
Cat. No.:
HY-100877
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