GOAT-IN-1
Based on 1 Customer Validation
GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.
For research use only. We do not sell to patients.
- Purity : 99.38%
- CAS No.: 1452473-54-9
- Formula: C18H13ClF3NO3S
- Molecular Weight:415.81
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
The inhibitory activity of GOAT-IN-1 (Example 16) for human GOAT is 101% with the concentration of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1452473-54-9
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Appearance Solid
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Molecular Weight 415.81
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Formula C18H13ClF3NO3S
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Color White to off-white
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SMILES
CC1=NC(C(F)(F)F)=CC=C1COC2=CC(SC=C3CC(O)=O)=C3C(Cl)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 150 mg/mL (360.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4049 mL | 12.0247 mL | 24.0494 mL | 60.1236 mL |
| 5 mM | 0.4810 mL | 2.4049 mL | 4.8099 mL | 12.0247 mL | |
| 10 mM | 0.2405 mL | 1.2025 mL | 2.4049 mL | 6.0124 mL | |
| 15 mM | 0.1603 mL | 0.8016 mL | 1.6033 mL | 4.0082 mL | |
| 20 mM | 0.1202 mL | 0.6012 mL | 1.2025 mL | 3.0062 mL | |
| 25 mM | 0.0962 mL | 0.4810 mL | 0.9620 mL | 2.4049 mL | |
| 30 mM | 0.0802 mL | 0.4008 mL | 0.8016 mL | 2.0041 mL | |
| 40 mM | 0.0601 mL | 0.3006 mL | 0.6012 mL | 1.5031 mL | |
| 50 mM | 0.0481 mL | 0.2405 mL | 0.4810 mL | 1.2025 mL | |
| 60 mM | 0.0401 mL | 0.2004 mL | 0.4008 mL | 1.0021 mL | |
| 80 mM | 0.0301 mL | 0.1503 mL | 0.3006 mL | 0.7515 mL | |
| 100 mM | 0.0240 mL | 0.1202 mL | 0.2405 mL | 0.6012 mL |
GOAT-IN-1 Related Classifications
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