Marine algae

Sargachromanol E is an apoptosis inducer, anti-inflammatory agent, and anti-aging agent. Sargachromanol E activates caspase-3, mediates PARP cleavage, downregulates Bcl-xL and upregulates Bax levels, and drives sub-G1 phase cell cycle arrest, inhibits LPS-induced COX-2 and iNOS transcription and expression (NO: IC₅₀ = 6.99 μg/mL), reduces p38 MAPK and ERK1/2 phosphorylation levels, and suppresses the release of pro-inflammatory mediators such as TNF-α, IL-1β, and prostaglandin E₂ (PGE₂). Sargachromanol E can be used for research on skin aging, leukemia, oral squamous cell carcinoma, and inflammation-related studies.

Aegagropila linnaei polysaccharide is a polysaccharide derived from Aegagropila linnaei.

(+)-Neoalbaconol is a selective Akt/PDK1 inhibitor (with an IC₅₀ of 10 μM against hPDK1). (+)-Neoalbaconol selectively inhibits cancer cell proliferation, and induces energy depletion, apoptosis, autophagy and necroptosis in cancer cells. In addition, (+)-Neoalbaconol downregulates cIAP1/2 and TRAFs to activate non-canonical NF-κB and promote TNFα transcription, blocks EGFR-mediated VEGF production and receptor activation, and mediates cell necrosis via the RIPK3-ROS-dependent pathway. (+)-Neoalbaconol can be used in research related to nasopharyngeal carcinoma, melanoma, breast cancer and gastric cancer.

Dictyvaric acid ((+)-Dictyvaric acid) is a novel sesquiterpene-substituted benzoic acid-type marine secondary metabolite isolated from the brown alga Dictyopteris divaricata. Dictyvaric acid’s congeneric analogs exhibit anti-tumor and antibacterial biological potential, and sulfide and sesquiterpene hydroquinone derivatives from congeneric algae can target EGFR and VEGFR kinases. Dictyvaric acid can be used in research related to cancers such as liver cancer and breast cancer.

(+)-Yahazunone is a bioactive marine pimarane-type meroterpenoid antifungal agent, with an EC₅₀ value of 28.7 μM against Sclerotinia sclerotiorum. (+)-Yahazunone is applicable to studies related to Sclerotinia sclerotiorum infection.

Makisterone A 2-acetate is a steroid compound that can be isolated from the 75% ethanol extract of Cyanotis arachnoidea. Experimental tests show that Makisterone A 2-acetate has no anti-HSV-1 activity.

Stellettamide A TFA is a marine toxin found in a marine sponge. Stellettamide A TFA is a calmodulin inhibitor. Stellettamide A TFA can inhibit Ca²⁺/Mg²⁺ ATPase, phosphodiesterase, myosin light chain , and Mg²⁺-ATPase. Stellettamide A TFA inhibits high K⁺- and Ca²⁺-induced contraction in permeabilized smooth muscle. Stellettamide A TFA exhibits antifungal activity against Mortierella remannianus. Stellettamide A TFA can be used for the research of fungal infection.

Ishophloroglucin A is an orally active phlorotannin compound found in Ishige okamurae. Ishophloroglucin A can alleviate Dexamethasone (HY-14648)-induced muscle atrophy through muscle protein metabolism. Ishophloroglucin A can improve impaired protein synthesis (PI3K and Akt) or degradation (muscle-specific ubiquitin ligase muscle RING finger and atrogin-1). Ishophloroglucin A can be used for research of muscle atrophy-related diseases.

(-)-Zonarol is an antifungal agent. (-)-Zonarol exhibits divergent translational potential. (-)-Zonarol is an isomer of Zonarol. Zonarol is a (-)-Yahazunol-related natural product.

Spheroidenone is an organic carbon source isolated from the metabolites of aerobic anoxic cells of marine dinoflagellates.

Filiformin ((-)-Filiformin) is a sesquiterpene compound that can be isolated from Laurencia filiformis forma heteroclada. Filiformin exhibits certain cytotoxicity against P388 and BSC-1 cells. Filiformin has antimicrobial activity against Bacillus subtilis, Trichophyton mentagrophytes and Candida albicans. In addition, Filiformin can inhibit oxygen uptake in isolated rat liver mitochondria at a concentration of 150 μM.

Buclizine (dihydrochloride) (Standard) is the analytical standard of Buclizine (dihydrochloride). This product is intended for research and analytical applications. Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity.

Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC₅₀ of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC₅₀ of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria.

Tasiamide B is a Cathepsin D inhibitor, which is a linear peptide found in the marine cyanobacteria Symploca sp.. Tasiamide B is proved as a good template for the development of aspartic proteases inhibitors. Tasiamide B is effective against skin cancer by strongly interacting with the target protein HSP90.

D-Nonamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Nonamannuronic acid can be used for the research of pain and vascular dementia.

D-Octamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Octamannuronic acid can be used for the research of pain and vascular dementia.

D-Heptamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Heptamannuronic acid can be used for the research of pain and vascular dementia.

D-Hexamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Hexamannuronic acid can be used for the research of pain and vascular dementia.

Methyl stearidonate is a secondary metabolite that can be isolated from Padina tenuis. Methyl stearidonate can be used for the research of type 2 diabetic.

Diadinochrome, a carotenoid, is a rearrangement product of diadinoxanthin that is produced by acidic catalysis during extraction.