1. GPCR/G Protein
  2. Leukotriene Receptor
  3. ONO4057

ONO4057 (Synonyms: ONO-LB457)

Cat. No.: HY-U00252
Handling Instructions

ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.

For research use only. We do not sell to patients.

ONO4057 Chemical Structure

ONO4057 Chemical Structure

CAS No. : 134578-96-4

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Description

ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.

IC50 & Target[1]

LTB4

0.7 μM (IC50)

In Vivo

Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2].

Molecular Weight

470.55

Formula

C₂₇H₃₄O₇

CAS No.

134578-96-4

SMILES

O=C(O)CCC1=C(OCCCC/C=C/C2=CC=C(OC)C=C2)C=CC=C1OCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[2]

Inbred male ACI (180 to 210 g) and LEW (200 to 240 g) rats are used as donors and recipients. Liver transplantation is orthotopically performed. ONO4057 dissolved in 7% NaHCO3 or solvent is administered subcutaneously daily after transplantation. Animals are divided into two groups: group I (n=5), 7% NaHCO3 3 mL/kg as controls; group II (n=6), ONO4057 30 mg/kg per day[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

ONO4057ONO-LB457ONO 4057ONO-4057Leukotriene ReceptorInhibitorinhibitorinhibit

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