Penicillin G potassium
Based on 28 publication(s) in Google Scholar
Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas.
For research use only. We do not sell to patients.
- Purity : 99.74%
- CAS No.: 113-98-4
- Formula: C16H17KN2O4S
- Molecular Weight:372.48
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Storage:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Penicillin G potassium
More- Cancer Res. 2023 Apr 4;83(7):1048-1061. [Abstract]
- Theranostics. 2022 Jan 1;12(3):1187-1203. [Abstract]
- Genes Dis. 2025 Apr 9;13(2):101625. [Abstract]
- Adv Sci (Weinh). 2025 Jul 17:e03098. [Abstract]
- J Control Release. 2024 Dec:376:1316-1328. [Abstract]
- J Neuroinflammation. 2025 Aug 26;22(1):207. [Abstract]
- NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. [Abstract]
- Phytomedicine. 2025 Dec:149:157553. [Abstract]
- EBioMedicine. 2022 Apr;78:103943. [Abstract]
- Talanta. 2026 Jul 15;312(Pt A):130306.
- Eur J Med Chem. 2024 Dec 5:279:116842. [Abstract]
- Int Immunopharmacol. 2026 Oct 1:186:117098.
- Int Immunopharmacol. 2026 Feb 1:170:116080. [Abstract]
- Int Immunopharmacol. 2024 Feb 15:128:111524. [Abstract]
- Cancers (Basel). 2022 Sep 28;14(19):4740. [Abstract]
- Neuropharmacology. 2026 Jul 1:292:110950. [Abstract]
- Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. [Abstract]
- BMC Complement Med Ther. 2023 Jul 1;23(1):218. [Abstract]
- Front Physiol. 2020 Dec 23:11:605982. [Abstract]
- Microbiol Spectr. 2025 Oct 15:e0122125. [Abstract]
- Anal Bioanal Chem. 2025 Jan;417(3):615-625. [Abstract]
- BMC Cancer. 2023 Mar 14;23(1):241. [Abstract]
- Water. 2025 Jun 6.
- Oncol Lett. 2025 Jun 10;30(2):387. [Abstract]
- In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1046-1057. [Abstract]
- Authorea. 2026 May 12.
- Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7419-7429. [Abstract]
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
Customer Validation & Images
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Microbiological Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Bio/Physico-chemical Assay
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WB
All Antibiotic Isoforms
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Biological Activity
Description
IC50 & Target
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β-lactam |
In Vitro
Penicillin G (16-128 μg/mL, 0-20 h) is used in combination with promethazine (32 μg/mL) to inhibit the growth and viability of E. coli[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 113-98-4
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Appearance Solid
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Molecular Weight 372.48
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Formula C16H17KN2O4S
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Color White to off-white
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SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O[K]
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Synonyms
Benzylpenicillin potassium
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Initial Source
Penicillium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (28)
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Journal Impact Factor
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Most Recent
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Cancer Res
HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression. [Abstract]2023 Apr 4;83(7):1048-1061. PMID: 36745032 -
Theranostics
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. [Abstract]2022 Jan 1;12(3):1187-1203. PMID: 35154482 -
Genes Dis
Low expression of OXCT1 promote colorectal cancer liver metastasis by upregulating CDK8 and β-catenin via H3 acetylation. [Abstract]2025 Apr 9;13(2):101625. PMID: 41492470 -
Adv Sci (Weinh)
2025 Jul 17:e03098. PMID: 40673882
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 17:e03098. [Abstract]
Colony formation assays evaluated Staphylococcus aureus (ATCC 6538) after Penicillin G (Penicillin G potassium; 50-100 μM; 12 or 24 h). Penicillin G (50 and 100 μm) had good inhibition effects against S. aureus (ATCC6538) for 12 and 24 h.
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 17:e03098. [Abstract]
Bacterial colonies and viable bacterial burden in wound tissue were assessed on day 3 in a mouse model of MRSA (USA300)-infected wounds. Penicillin G (Penicillin G potassium; 100 μM; topical application to the wound; twice daily at 10 µL each time) significantly reduced the viable MRSA burden in the wound tissue.
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J Control Release
2024 Dec:376:1316-1328. PMID: 39490420 -
J Neuroinflammation
Disrupted betaine metabolism drives Th17 cell differentiation, mediating methamphetamine-induced depressive behaviors in male mice. [Abstract]2025 Aug 26;22(1):207. PMID: 40859333 -
NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
Phytomedicine
Liquiritigenin attenuates thrombosis by inhibiting P2Y12R-mediated Src/PLCγ2 signaling and cytoplasmic Ca2+ mobilization in platelets. [Abstract]2025 Dec:149:157553. PMID: 41273866 -
EBioMedicine
A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]2022 Apr;78:103943. PMID: 35306337 -
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Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319 -
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Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2026 Feb 1:170:116080. PMID: 41429063 -
Int Immunopharmacol
Hypidone hydrochloride (YL-0919) protects mice from meningitis via Sigma1R-STAT1-NLRP3-GSDMD pathway. [Abstract]2024 Feb 15:128:111524. PMID: 38232537 -
Cancers (Basel)
LncRNA SNHG1 Facilitates Tumor Proliferation and Represses Apoptosis by Regulating PPARγ Ubiquitination in Bladder Cancer. [Abstract]2022 Sep 28;14(19):4740. PMID: 36230661 -
Neuropharmacology
Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis. [Abstract]2026 Jul 1:292:110950. PMID: 41887568 -
Appl Microbiol Biotechnol
2022 Apr;106(7):2689-2702. PMID: 35338386 -
BMC Complement Med Ther
Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis. [Abstract]2023 Jul 1;23(1):218. PMID: 37393274 -
Front Physiol
Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms. [Abstract]2020 Dec 23:11:605982. PMID: 33424630
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) combined with streptomycin had greater wet cecum weight/body weight and net cecum weight/body weight in C57BL/6.
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) combined with streptomycin significantly increased the serum 5-HT concentration in C57BL/6.
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) combined with streptomycin significantly increased HCN2 expression in the cecal epithelium of C57BL/6.
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) led to significant reductions of acetic acid, butyrate, isobutyrate, and isovalerate levels but slight increases of propionate in the cecum, compared with the control group.
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) had larger and heavier cecum compared with the control mice.
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) had significant up-regulation of HCN2 expression in the cecal mucosa.
Penicillin G potassium purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL;drinking water for 10 days) significantly prolonged intestinal transit time and fecal water content.
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Microbiol Spectr
Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities. [Abstract]2025 Oct 15:e0122125. PMID: 41090944 -
Anal Bioanal Chem
2025 Jan;417(3):615-625. PMID: 39613988 -
BMC Cancer
Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma. [Abstract]2023 Mar 14;23(1):241. PMID: 36918801 -
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Oncol Lett
Propionate metabolism-related genes demonstrate the potential to serve as prognostic and immunotherapeutic markers in osteosarcoma. [Abstract]2025 Jun 10;30(2):387. PMID: 40535100 -
In Vitro Cell Dev Biol Anim
Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. [Abstract]2024 Oct;60(9):1046-1057. PMID: 39039329 -
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Eur Rev Med Pharmacol Sci
Novel long non-coding RNA LBX2-AS1 indicates poor prognosis and promotes cell proliferation and metastasis through Notch signaling in non-small cell lung cancer. [Abstract]2019 Sep;23(17):7419-7429. PMID: 31539129 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (268.47 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (268.47 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Roussel AJ, et al. Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses. Am J Vet Res. 2003 Nov;64(11):1360-3. [Content Brief]
[2]. Byra C, et al. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6. [Content Brief]
[3]. Lehtinen J, et al. Promethazine renders Escherichia coli susceptible to penicillin G: real-time measurement of bacterial susceptibility by fluoro-luminometry. Int J Antimicrob Agents. 2007 Jul;30(1):44-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6847 mL | 13.4235 mL | 26.8471 mL | 67.1177 mL |
| 5 mM | 0.5369 mL | 2.6847 mL | 5.3694 mL | 13.4235 mL | |
| 10 mM | 0.2685 mL | 1.3424 mL | 2.6847 mL | 6.7118 mL | |
| 15 mM | 0.1790 mL | 0.8949 mL | 1.7898 mL | 4.4745 mL | |
| 20 mM | 0.1342 mL | 0.6712 mL | 1.3424 mL | 3.3559 mL | |
| 25 mM | 0.1074 mL | 0.5369 mL | 1.0739 mL | 2.6847 mL | |
| 30 mM | 0.0895 mL | 0.4475 mL | 0.8949 mL | 2.2373 mL | |
| 40 mM | 0.0671 mL | 0.3356 mL | 0.6712 mL | 1.6779 mL | |
| 50 mM | 0.0537 mL | 0.2685 mL | 0.5369 mL | 1.3424 mL | |
| 60 mM | 0.0447 mL | 0.2237 mL | 0.4475 mL | 1.1186 mL | |
| 80 mM | 0.0336 mL | 0.1678 mL | 0.3356 mL | 0.8390 mL | |
| 100 mM | 0.0268 mL | 0.1342 mL | 0.2685 mL | 0.6712 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Penicillin G potassium Related Classifications
HY-17591 Related Classifications
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