1. Apoptosis
  2. Apoptosis
  3. RIPGBM

RIPGBM 

Cat. No.: HY-122910 Purity: 99.89%
Handling Instructions

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM.

For research use only. We do not sell to patients.

RIPGBM Chemical Structure

RIPGBM Chemical Structure

CAS No. : 355406-76-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1].

IC50 & Target

EC50: ≤500 nM (Apoptosis, in GBM CSCs)[1]

In Vitro

RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

428.45

Formula

C₂₆H₂₁FN₂O₃

CAS No.

355406-76-7

SMILES

CC(N(C(C1=O)=C(NCC2=CC=CC=C2)C(C3=C1C=CC=C3)=O)CC4=CC=C(F)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (77.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3340 mL 11.6700 mL 23.3399 mL
5 mM 0.4668 mL 2.3340 mL 4.6680 mL
10 mM 0.2334 mL 1.1670 mL 2.3340 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RIPGBMApoptosisInhibitorinhibitorinhibit

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RIPGBM
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HY-122910
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