2. Apoptosis
  3. Apoptosis
  4. RIPGBM

RIPGBM 

Cat. No.: HY-122910 Purity: 99.89%
COA Handling Instructions

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM.

For research use only. We do not sell to patients.

RIPGBM Chemical Structure

RIPGBM Chemical Structure

CAS No. : 355406-76-7

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 73 In-stock
Solid
5 mg USD 66 In-stock
10 mg USD 110 In-stock
25 mg USD 242 In-stock
50 mg USD 429 In-stock
100 mg USD 726 In-stock
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500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1].

IC50 & Target

EC50: ≤500 nM (Apoptosis, in GBM CSCs)[1]
In Vitro

RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

428.45

Appearance

Solid

Formula

C26H21FN2O3
CAS No.
SMILES

CC(N(C(C1=O)=C(NCC2=CC=CC=C2)C(C3=C1C=CC=C3)=O)CC4=CC=C(F)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (77.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3340 mL 11.6700 mL 23.3399 mL
5 mM 0.4668 mL 2.3340 mL 4.6680 mL
10 mM 0.2334 mL 1.1670 mL 2.3340 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RIPGBM355406-76-7ApoptosisInhibitorinhibitorinhibit

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