Infection

Dimethyl fumarate (Standard) is the analytical standard of Dimethyl fumarate. This product is intended for research and analytical applications. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.

mP6 (Myr-FEEERA-OH) TFA is a myristoylated peptide. mP6 TFA inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. mP6 TFA can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells.

Montmorillonite is a calcium-based 2:1 layered silicate clay mineral with excellent adsorption capacity, which can adsorb and immobilize a variety of substances, such as organic compounds, metal ions, and bacteria. Montmorillonite can serve as a nanoparticle carrier for research on functional nanocomposites for multiple scenarios, such as biomedical applications and food additives. Montmorillonite is also applicable to research related to wastewater treatment.

Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds.

Antibacterial agent 268 (Compound 10e) is an antibacterial agent with antimycobacterial properties. Antibacterial agent 268 shows high anti-bacterial properties at sub-micromolar values (MIC=0.44-0.07 μM).

Ronidazole (Standard) is the analytical standard of Ronidazole. This product is intended for research and analytical applications. Ronidazole is a potent and orally active antiprotozoal and anti-microbial agent. Ronidazole acts as a veterinary agent against Tritrichomonas foetus?in cats models. Ronidazole can be used the research of forhistomoniasis?and?swine?dysentery.

T3SS-IN-2 (Compound 2h) is a type three secretion system (T3SS) inhibitor. T3SS-IN-2 can be used for bacterial infection research.

Anti-Mouse CD8α Antibody (YTS169.4) is an IgG2 monoclonal antibody targeting mouse CD8α. Anti-Mouse CD8α Antibody (YTS169.4) rapidly depletes or downregulates CD8⁺ T cells in the spleens of Biozzi AB/H mice. Anti-Mouse CD8α Antibody (YTS169.4) is applicable to research related to hepatitis B virus infection. Recommended isotype control: Rat IgG2b kappa, Isotype Control (HY-P990682).

3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose.

2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD). In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine.
Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min.
In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain.
2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model.

Ametoctradin is a potent Q_o site inhibitor of bc₁ complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews.

Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist. Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities.

Z-Arg-Leu-Arg-Gly-Gly-AMC acetate is a peptide substrate for SARS-CoV PL^pro.

Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery.

CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC₅₀ of 40 nM.

Cereulide-¹³C₆ is a deuterated form of Cereulide. Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K⁺, and transports K⁺ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.

Nicotinohydrazide (Nicotinic acid hydrazide) is a precursor used for synthesizing hydrazone derivatives with antibacterial and antifungal activities. Nicotinohydrazide can be used in studies of bacterial and fungal infections.

Antimicrobial agent-48 (P119 103) is an antimicrobial agent. Antimicrobial agent-48 binds to paНО. Antimicrobial agent-48 exhibits a MIC₅₀ of >250 μg/mL. Antimicrobial agent-48 can be used in research on Escherichia coli infections.

Aromadendrene ((+)-Aromadendrene) is a potent antibacterial agent. Aromadendrene can be isolated from Eucalyptus globulus. Aromadendrene disrupts cellular biofilms via high lipophilicity and interferes with protein conformation through protein alkylation. Aromadendrene is applicable to research related to multidrug-resistant bacterial infections.

Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA. Phleomycin D1 induces cell cycle arrest at S phase.