Infection

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) is a kind of mouse IgG1 chimeric antibody inhibitor, targeting to human LFA-1α/CD11a. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) reacts with human LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) can be used for the researches of immunology and infection, such as human immunodeficiency virus (HIV).

Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA. Phleomycin D1 induces cell cycle arrest at S phase.

2-(p-Tolyl) propanoic acid (2-(4-methylphenyl) propionic acid) acts as an Antimicrobial agent intermediate. 2-(p-Tolyl) propanoic acid inhibits COX-1 and COX-2 enzymes, with IC₅₀ values of 38.23 μM and 64.30 μM, respectively. 2-(p-Tolyl) propanoic acid is applicable to research on E. coli, Enterococcus faecalis, Listeria monocytogenes, and Staphylococcus aureus.

Antimicrobial agent-48 (P119 103) is an antimicrobial agent. Antimicrobial agent-48 binds to paНО. Antimicrobial agent-48 exhibits a MIC₅₀ of >250 μg/mL. Antimicrobial agent-48 can be used in research on Escherichia coli infections.

(R)-Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N⁺-glucuronidation and sulfation. (R)-Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.

Aromadendrene ((+)-Aromadendrene) is a potent antibacterial agent. Aromadendrene can be isolated from Eucalyptus globulus. Aromadendrene disrupts cellular biofilms via high lipophilicity and interferes with protein conformation through protein alkylation. Aromadendrene is applicable to research related to multidrug-resistant bacterial infections.

Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important agent for African trypanosomiasis. Melarsoprol inhibits the growth of lymphoid leukemic cell by inducing apoptosis. Melarsoprol crosses the blood-brain barrier.

6-Chloro-7-deazapurine-β-D-riboside, a nucleoside derivative, exerts antifungal effects. 6-Chloro-7-deazapurine-β-D-riboside shows activity against plant pathogenic fungi.

Isoeugenol-d₃ is deuterated labeled Isoeugenol (HY-N1952). Isoeugenol is an essential oil constituent of nutmeg, clove, and cinnamon. Isoeugenol inhibits growth of Escherichia coli and Listeria innocua with MICs of 0.6 mg/mL and 1 mg/mL, respectively.

Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 influenza A viruses and the influenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity.

Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes. IC₅₀ & Target: GAD. In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal.

Myristoyl coenzyme A triammonium (14:0 Coenzyme A) is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

D-Phenylalanine (Standard) is the analytical standard of D-Phenylalanine. This product is intended for research and analytical applications. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014.

Dehydroacetic acid (Biocide 470F) is a pyrone derivative. Dehydroacetic acid has antibacterial, antifungal and phytotoxic activities. Dehydroacetic acid can be added to cosmetics, food and beverages for preservation and other purposes. Dehydroacetic acid can also be used to synthesize various heterocycles and cycloaddition products.

Desfuroylceftiofur is an antibacterial agent and the active metabolite of Ceftiofur sodium (HY-B0898) with an intact β-lactam ring. Desfuroylceftiofur exhibits inhibitory activity against Gram-negative and Gram-positive pathogenic bacteria of veterinary interest in vitro. Desfuroylceftiofur can be used in the research of bovine respiratory disease, porcine respiratory disease, equine lymphadenitis, bovine mastitis, turkey colibacillosis, suppurative arthritis and respiratory infections.

Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle.

NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC₅₀ of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects.

NHS-PEG2000-Mannose is an NHS-PEG-Mannose containing PEG2000. NHS-PEG-Mannose is a D-mannose derivative and linker. NHS-PEG-Mannose can bind to phage coat proteins via amino-carboxyl reaction to form mannose-modified phage (Man-phage).

Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.

Fendiline (hydrochloride) (Standard) is the analytical standard of Fendiline (hydrochloride). This product is intended for research and analytical applications. Fendiline hydrochloride, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC50 of 17 µM). Fendiline hydrochloride is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline hydrochloride inhibits K-Ras plasma membrane localization (IC50 of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline hydrochloride is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10).