Infection

PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC₅₀ values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV).

Methyl indole-3-carboxylate is a Sorangium metabolite. Methyl indole-3-carboxylate shows weak activity against Gram-positive Nocardia sp with a MIC of 33.3 μg/mL.

Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent.

Anti-Rat CD8α Antibody (OX-8) is an anti-rat CD8α IgG1 monoclonal antibody. Anti-Rat CD8α Antibody (OX-8) can deplete CD8⁺ T cells. Anti-Rat CD8α Antibody (OX-8) can enhance airway remodeling. Anti-Rat CD8α Antibody (OX-8) can be used for researches on allergic conditions and infections such as RHV-rn1 virus infection and asthma.

Lomefloxacin (SC47111A) is an orally active difluoroquinolone antibiotic. Lomefloxacin prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin induces ROS production and Apoptosis. Lomefloxacin has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin has anticancer effects against melanoma. Lomefloxacin can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma .

Potassium 1,2-naphthoquinone-4-sulphonate (Compound 16) is a 6-phosphogluconate dehydrogenase (6PGDH) inhibitor with an IC₅₀ of 53 μM. Potassium 1,2-naphthoquinone-4-sulphonate can be used in the study of human African trypanosomiasis.

2'-Deoxyuridine-¹³C,¹⁵N₂ is the ¹³C and ¹⁵N labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

Procyanidin B5 is an antioxidant with a IC₅₀ of 0.1 mM in lipid peroxidation assays using mouse liver homogenates. Procyanidin B5 scavenges superoxide anions and hydroxyl radicals, and inhibits lipid peroxidation. Procyanidin B5 can be used in research related to cardiovascular diseases, cancer, and malaria.

Cefoperazone (sodium salt) (Standard) is the analytical standard of Cefoperazone (sodium salt). This product is intended for research and analytical applications. Cefoperazone sodium salt (CP 52640-2), a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.

Loracarbef hydrate, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class.

ITGB3-IN-1 is an orally active integrin subunit beta 3 ITGB3 inhibitor with a K_d of 7.26 μM. ITGB3-IN-1 exhibits potent anti-orthopoxvirus effects with an EC₅₀ for vaccinia virus (VACV) of 1.82 μM. ITGB3-IN-1 inhibits hERG with an IC₅₀ of 1.13 μM. ITGB3-IN-1 can be used for the study of orthopoxvirus.

Levofloxacin Q-acid (Levofloxacin carboxylic acid) is an intermediate in the synthesis of the antibiotic Levofloxacin (HY-B0330).

Guanosine-d13 (DL-Guanosine-d13) is a deuterium of Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

7-Methyl-DL-tryptophan (7-Methyltryptophan) is an anthranilate synthase inhibitor that inhibits tryptophan biosynthesis. 7-Methyl-DL-tryptophan is also a tryptophan analog. 7-Methyl-DL-tryptophan can cause growth inhibition in tobacco, whereas a feedback-insensitive anthranilate synthase confers resistance and can be used as a selective agent to recover transgenic tobacco plants expressing this enzyme.

Retusin (Quercetin-3,3',4',7-tetramethylether) is a tyrosinase inhibitor, with IC₅₀ values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS•⁺ and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection.

Albendazole (Standard) is the analytical standard of Albendazole. This product is intended for research and analytical applications. Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells.

VSV-G tag Peptide is a 11 amino acid peptide derived from the Vesicular Stomatitis viral glycoprotein. VSV-G tag Peptide can integrate into the cell membranes of animal cells, induce cell fusion, and significantly enhance the efficiency of DNA transfection into animal cells. VSV-G tag Peptide can be used for research on drug delivery.

(+)-SJ733 is an anti-malaria agent which can also inhibit Na⁺-ATPase PfATP4.

Chloroquine-d₅ is deuterium labeled Chloroquine (HY-17589A). Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM).

AIN-93M, a modified version of AIN-76A (HY-AF0001), is a formula of a purified diet for experimental rodents. AIN-93M to be used during adult maintenance. AIN-93M is typically used as a control group for drug-additive feeds. The feed ingredient meet the US AIN-93 standard.