Infection

Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis.

Euphominoid L is a diterpenoid EBV lytic replication inhibitor that can be found in the aerial parts of Euphorbia milii and shows oral activity. Euphominoid L suppresses EBV lytic replication. Euphominoid L can be used for the research of EBV virus infection.

HIV-1 inhibitor-58 (Compound 10c) is a broad-spectrum antiviral agent. HIV-1 inhibitor-58 is a non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-58 inhibits WT strain IIIB, NNRTI-resistant strains (such as K103N and E138K) in MT-4 cells, with EC₅₀ less than 50 nM. HIV-1 inhibitor-58 also inhibits CYP2C9 and CYP2C19 (IC₅₀: 2.06 μM, 1.91 μM). HIV-1 inhibitor-58 can be used for HIV infection reserch.

(-)-Mecambridine (Compound 2) is a retroprotoberberine alkaloid found in Papaver pseudocanescens M. Pop. (-)-Mecambridine has weak inhibitory activity against poliovirus type 1.

SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC₅₀ value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice.

Chamaejasmenin C, a biflavanone, shows nematicidal activity against second-stage juveniles (J2s) of B. xylophilus and B. mucronatus.

Etravirine-d₄ is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

Momilactone A is a naturally derived diterpene lactone with multiple biological activities including anticancer, antibacterial and antioxidant properties. Momilactone A inhibits inflammatory responses by reducing NO production and iNOS expression. Momilactone A acts as a corrosion inhibitor for mild steel; it forms an isolating film on the metal surface via adsorption between oxygen atoms of the molecule and iron ions, thereby blocking corrosive media. Momilactone A inhibits the growth of fungal and bacterial organisms, and also functions as an allelochemical to inhibit the growth of adjacent competing plants. Momilactone A can be used in studies related to leukemia, fungal infections and bacterial infections.

NNRT-IN-13 is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor that directly inhibiting HIV-1 reverse transcriptase (IC₅₀ = 0.25 μM). NNRT-IN-13 exhibits excellent antiviral activity against wild-type HIV-1 (EC₅₀ = 0.0046 μM) and a broad spectrum of drug-resistant mutants. NNRT-IN-13 exhibits favorable in vivo metabolic and safety profiles. NNRT-IN-13 can be used for human immunodeficiency virus (HIV) research.

Cefetamet-d₃ (Ro 15-8074-d₃; Deacetoxycefotaxime-d₃) is the deuterium labeled Cefetamet (HY-A0111). Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC₅₀ for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.

Geranyl ferulate ((E)-geranylferulic acid), isolated from Zingiber officinale, exhibits inhibitory effect on the production of nitric oxide (NO).

Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities.

Spirodiclofen (BAJ-2740) (Standard) is the analytical standard of Spirodiclofen. This product is intended for research and analytical applications. Spirodiclofen is a broad spectrum acaricide acting via lipid biosynthesis inhibition (LBI) with no cross resistance to currently available acaricides and with additional insecticidal properties.

TP0586352 is a LpxC inhibitor that is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. TP0586352 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

UA2239 is an antimalarial agent and acyclic nucleoside phosphonate. UA2239 disrupts the essential cGMP-dependent egress pathway by decreasing cGMP levels. UA2239 targets guanylyl cyclase α. UA2239 demonstrates rapid and irreversible inhibitory effects on Plasmodium parasites.

Antimicrobial agent-53 is an antimicrobial agent. Antimicrobial agent-53 can be used in the research of tuberculosis and methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) infections.

Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a Penicillinase (HY-E70012)- resistant penicillin with antibacterial activity. Diphenicillin shows good antibacterial effects against Gram-positive cocci. Diphenicillin is promising for research of infectious diseases caused by Gram-positive cocci such as staphylococci, pneumococci, and group A streptococci.

Spinosyn K is an insecticide found in the actinomycete Saccharopolyspora spinosa. Spinosyn K shows strong insecticidal activity.

Antibacterial agent 191 (compound 11a) is a potent semi-synthetic antibiotic. Antibacterial agent 191 exhibits preferable metabolic stability.