2. Anti-infection
  3. Reverse Transcriptase HIV
  4. Etravirine-d4

Etravirine-d4  (Synonyms: TMC-125 d4; R-165335 d4)

Cat. No.: HY-90005S Purity: 98.31%
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Etravirine-d4 is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

For research use only. We do not sell to patients.

Etravirine-d<sub>4</sub> Chemical Structure

Etravirine-d4 Chemical Structure

CAS No. : 1142095-93-9

Size Price Stock Quantity
1 mg USD 160 In-stock
5 mg USD 730 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Etravirine-d4:

Etravirine-d4 Related Antibodies

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Description

Etravirine-d4 is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Molecular Weight

439.30

Formula

C20H11D4BrN6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=C(Br)C(OC2=C(C)C=C(C#N)C=C2C)=NC(NC3=C([2H])C([2H])=C(C#N)C([2H])=C3[2H])=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (569.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2763 mL 11.3817 mL 22.7635 mL
5 mM 0.4553 mL 2.2763 mL 4.5527 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (4.73 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2763 mL 11.3817 mL 22.7635 mL 56.9087 mL
5 mM 0.4553 mL 2.2763 mL 4.5527 mL 11.3817 mL
10 mM 0.2276 mL 1.1382 mL 2.2763 mL 5.6909 mL
15 mM 0.1518 mL 0.7588 mL 1.5176 mL 3.7939 mL
20 mM 0.1138 mL 0.5691 mL 1.1382 mL 2.8454 mL
25 mM 0.0911 mL 0.4553 mL 0.9105 mL 2.2763 mL
30 mM 0.0759 mL 0.3794 mL 0.7588 mL 1.8970 mL
40 mM 0.0569 mL 0.2845 mL 0.5691 mL 1.4227 mL
50 mM 0.0455 mL 0.2276 mL 0.4553 mL 1.1382 mL
60 mM 0.0379 mL 0.1897 mL 0.3794 mL 0.9485 mL
80 mM 0.0285 mL 0.1423 mL 0.2845 mL 0.7114 mL
100 mM 0.0228 mL 0.1138 mL 0.2276 mL 0.5691 mL
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Etravirine-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etravirine-d41142095-93-9TMC-125 d4R-165335 d4Reverse TranscriptaseHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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