Infection

Efrotomycin is an orally active antibiotic. Efrotomycin can be isolated from the Streptomyces Lactamdurans. Efrotomycin has insignificant effect on Salmonella typhimurium quantity, duration, shedding rate, and antimicrobial susceptibility in infected pigs.

CF 1743-d₇ is the deuterium labeled Cf1743 (HY-107025). Cf1743 is a potent anti-varicella-zoster virus (VZV) bicyclic nucleoside analogue. Cf1743 has antiviral activity, with an IC₅₀ of 3.3 μM for VZV thymidine kinase (TK).

Chloroorienticin A (A82846B) is a glycopeptide antibiotic. Chloroorienticin A exhibits excellent activity against staphylococci and streptococci.

GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC₅₀s of 1, 180, 1, and 40 nM for III_B, III_B-R(Y181C), NL4-3 and NL4-3_K103N of HIV-1 strains, respectively.

Oseltamivir-d₃ (phosphate)eis the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

COX-2-IN-65 is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 10.24 μM. COX-2-IN-65 inhibits Staphylococcus aureus and Escherichia coli growth. COX-2-IN-65 scavenges reactive oxygen species (ROS). COX-2-IN-65 can be used for the researches of bacterial infections and inflammation.

N-Desmethylclozapine (Standard) is the analytical standard of N-Desmethylclozapine. This product is intended for research and analytical applications. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.

Antifungal agent 65 (Compound 5d) is a fungicidal agent with excellent fungicidal activities against Fusarium oxysporum f.sp. cucumerinum. Antifungal agent 65 can be used for antiviral and fungicidal research.

4-Methyltridecane is a volatile substance specifically released by cabbage root flies (Delia radicum) after feeding. 4-Methyltridecane might be a key signal for the parasitoid bee Trybliographa rapae (Delia radicum’s specific parasitic predator) to locate the host. 4-Methyltridecane can serve as a specific marker for root damage in turnips (Brassica rapa subsp. Rapa).

Carbendazim hydrochloride is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina. Carbendazim hydrochloride is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.

Urease-IN-12 (compound 5e) is a competitive urease inhibitor (IC₅₀: 0.35 μM) with the potential to inhibit gastritis and peptic ulcer caused by Helicobacter pylori.

(S,R,S)-AHPC-Me-C2-piperazine is an E3 ligase ligand-linker conjugate containing an E3 ligase ligand (HY-112078) and a PROTAC linker. (S,R,S)-AHPC-Me-C2-piperazine can be used in the PROTAC SARS-CoV-2 Mpro degrader-8 (HY-181870).

Anti-MRSA agent 15 (Compound 9o10) exhibits antibacterial activity, that inhibits methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 0.0625 μg/mL. Anti-MRSA agent 15 exhibits low hemolysis and low cytotoxicity. Anti-MRSA agent 15 exhibits anti-infective in mice.

GE 2270A (MDL 62879) is an antibiotic. GE 2270A inhibits gram-positive bacteria and anaerobes by inhibiting protein synthesis. GE 2270A can be used for the research of infection.

SARS-CoV-2 3CLpro-IN-27 (Compound 9H) is an inhibitor of SARS-CoV-2 3CL^pro with an IC₅₀ value of 21 nM. SARS-CoV-2 3CLpro-IN-27 exhibits excellent anti-SARS-CoV-2 replicon activity, demonstrating an EC₅₀ value of 5 nM.

CD4 (81-92) (human) is a fragment of hCD4. CD4 (81-92) (human) can undergo structural modifications including derivatization and cyclization to enhance antiviral potency and stability, with sequence alterations affecting its activity. CD4 (81-92) (human) is applicable to studies related to HIV-1 infection.

MI-30 is an orally active SARS-CoV-2 3CLpro inhibitor (IC₅₀ = 17.2 nM). MI-30 reduces viral load and lung lesions in a mouse model of SARS-CoV-2 infection. MI-30 may be used in coronavirus infection research.

Septeremophilane E is a compound isolated from fungus Septoria rudbeckiae, a plant pathogenic fungus isolated from the halophyte Karelinia caspia. Septeremophilane E significantly inhibits the production of nitric oxide (NO).

16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) is a prostaglandin analog that can inhibit DNA synthesis in Lewis lung carcinoma and B 16 amelanotic melanoma cells. 16,16-Dimethyl prostaglandin A1 also inhibits viral replication in both HSV and HIV-1 infection systems.

GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection.