Infection

Dehydroabietic acid (Standard) is the analytical standard of Dehydroabietic acid. This product is intended for research and analytical applications. Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice.

N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) Standard of N4-Acetylsulfamethoxazole (HY-W013266). This product is intended for research and analytical applications. N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is the N4-acetylated metabolite of Sulfamethoxazole (HY-B0322).

SARS-CoV-2 nsp13-IN-6 (compound C5) is a potent SARS-CoV-2 non-structural protein 13 (nsp13) inhibitor with IC₅₀ values of 27 and 33 μM for ssDNA⁺ ATPase and ssDNA^- ATPase. SARS-CoV-2 nsp13-IN-6 can be used for researching anti-COVID-19.

HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC₅₀ of 21 pM and a K_i of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus.

Antibacterial agent 232 (compound Y41) is a potent antibacterial agent. Antibacterial agent 232 disrupts the cell membrane integrity by inducing cell peroxidation.

mCMY416 is an orally active and blood brain barrier (BBB) permeability apicomplexan phenylalanine tRNA synthetase inhibitor, and shows antiparasitic activity .

Ketotifen-¹³C,d₃ is deuterium labeled Ketotifen.

Erisonersen sodium, an antisense oligonucleotide, is a prion protein synthesis reducer. It is used for the study of Prion disease.

Spiroamantadine (DU-34569 maleate) is a compound related to Amantadine (HY-B0402) with anti-influenza virus activity.

Saflufenacil (Standard) is the analytical standard of Saflufenacil. This product is intended for research and analytical applications. Saflufenacil is a herbicide of the pyrimidinedione chemical class preplant burndown and selective preemergence dicot weed control in multiple crops, including corn. Saflufenacil is a potent inhibitor of protoporphyrinogen IX oxidase (PPO).

Hb 98-114, the amino acids 98-114 of the alpha subunit of bovine hemoglobin, is an antimicrobial peptide. Hb 98-114 is active against several yeast and filamentous fungi (MIC: 2.1 μM-12.5 μM).

SARS-CoV-2-IN-29 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-29 disodium exhibits antiviral activity with IC₅₀s of 1.5 μM and 1.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-29 disodium induces liposomal membrane disruption with an EC₅₀ value of 3.0 μM.

Spergualin trihydrochloride is a natural occurring antibiotic initially identified from culture filtrates of Bacillus laterosporus BMG162-aF2.

Isoleucyl tRNA synthetase-IN-2 (compound 36a) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a K_i,app of 114 nM.

Antifeedant agent 1 is a carboxylesterase inhibitor that exerts insecticidal activity by inhibiting insect feeding, with an EC₅₀ value of 0.038 mg/mL. Antifeedant agent 1 can be used in research related to pest control.

HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor, with an IC₅₀ of 33.3 nM.

1-Tetradecanol-d₂₉ is the deuterium labeled 1-Tetradecanol. 1-Tetradecanol, isolated from Myristica fragrans, is a straight-chain saturated fatty alcohol. 1-Tetradecanol possesses antibacterial and anti-inflammatory (periodontitis) activity.

Amenamevir-d₆ (ASP2151-d₆) is the deuterium labeled Amenamevir (HY-14809). Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC₅₀ of 14 ng/mL.

Antibacterial agent 271 is an antibacterial agent with significant inhibition against Escherichia coli (MIC: 2.2 μM). Antibacterial agent 271 reduces metabolic activity by disrupting the integrity of bacterial membranes. Antibacterial agent 271 binds to DNA grooves to inhibit replication and induces accumulation of reactive oxygen species (ROS) , ultimately leading to bacterial death. Antibacterial agent 271 shows significant potential in combating bacterial infections.

Ent-Avibactam (NXL-104) sodium is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), rel-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC₅₀ value of rel-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes.