751-97-3
751-97-3
Chemical Structure
Rolitetracycline
- CAS. Nr.: 751-97-3
- Formula:C27H33N3O8
- Molecular Weight:527.57
IUPAC Name: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(pyrrolidin-1-ylmethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
InChIKey: HMEYVGGHISAPJR-IAHYZSEUSA-N
SMILES: O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@](C)(O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4)NCN5CCCC5
Biological Activity:
Rolitetracycline is a highly soluble, broad-spectrum antibiotic derived from tetracycline. Rolitetracycline binds to and stabilizes bovine serum albumin, and also inhibits HIV-1 integrase, blocks Aβ fibril formation and suppresses dengue virus proliferation. Rolitetracycline mediates the inhibition of Aβ fibrils via a specific three-dimensional pharmacophore conformation, and exerts bacteriostatic and bactericidal activities. Rolitetracycline acts synergistically with Penicillin G (HY-N7139) or Cephalothin (HY-B1275A) to alter the effects on microbial growth. Rolitetracycline serves as an important tool compound for the study of bacterial infections (urinary tract infections, sepsis), HIV-1 and dengue virus infections, as well as Alzheimer's disease[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Rolitetracycline | 95.0% | Rolitetracycline is a highly soluble, broad-spectrum antibiotic derived from tetracycline. Rolitetracycline binds to and stabilizes bovine serum albumin, and also inhibits HIV-1 integrase, blocks Aβ fibril formation and suppresses dengue virus proliferation. Rolitetracycline mediates the inhibition of Aβ fibrils via a specific three-dimensional pharmacophore conformation, and exerts bacteriostatic and bactericidal activities. Rolitetracycline acts synergistically with Penicillin G (HY-N7139) or Cephalothin (HY-B1275A) to alter the effects on microbial growth. Rolitetracycline serves as an important tool compound for the study of bacterial infections (urinary tract infections, sepsis), HIV-1 and dengue virus infections, as well as Alzheimer's disease. |
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Rolitetracycline (Standard) | ≥98% | Saflufenacil (Standard) is the analytical standard of Saflufenacil. This product is intended for research and analytical applications. Saflufenacil is a herbicide of the pyrimidinedione chemical class preplant burndown and selective preemergence dicot weed control in multiple crops, including corn. Saflufenacil is a potent inhibitor of protoporphyrinogen IX oxidase (PPO). | ||||||||||||||||||||
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Lymecycline | 95.0% | Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity and also has anti-inflammatory property. | ||||||||||||||||||||
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Guamecycline | Guamecycline is a semisynthetic tetracycline. The antibacterial spectrum and antibacterial activity are the same as Tetracycline. | |||||||||||||||||||||
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4-Epitetracycline hydrochloride (Standard) | ≥98% | 4-Epitetracycline (hydrochloride) (Standard) is the analytical standard of 4-Epitetracycline (hydrochloride). This product is intended for research and analytical applications. 4-Epitetracycline hydrochloride is a reversible epimer of Tetracycline (HY-A0107) that can be interconverted in nature. 4-Epitetracycline hydrochloride exhibits antibacterial activity. | ||||||||||||||||||||
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4-epi-Chlortetracycline hydrochloride | 4-epi-Chlortetracycline hydrochloride is an epimetabolite of Chlortetracycline hydrochloride. Chlortetracycline hydrochloride is an orally active, potent and selective inhibitor of methanogenic bacteria with bactericidal effect. | |||||||||||||||||||||
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Tetracycline | 98.0% | Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections. | ||||||||||||||||||||
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Tetracycline-d6 | 97.15% | Tetracycline-d6 is the deuterium labeled Tetracycline. Tetracycline is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria. | ||||||||||||||||||||
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Tetracycline hydrochloride (Standard) | 99.22% | Tetracycline (hydrochloride) (Standard) is the analytical standard of Tetracycline (hydrochloride). This product is intended for research and analytical applications. Tetracycline (hydrochloride) is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria. | ||||||||||||||||||||
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Chlortetracycline | Chlortetracycline (7-Chlorotetracycline) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes. | |||||||||||||||||||||
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2-Acetyl-2-decarboxamidotetracycline | 2-Acetyl-2-decarboxamidotetracycline (2-Acetyl-2-decarboxamidooxytetracycline) is an antibiotic of the tetracycline type. 2-Acetyl-2-decarboxamidotetracycline shows an ultraviolet absorption spectrum which is identical with that of tetracycline or of 5-oxytetracycline above 300 mμ, a region characteristic of the BCD-ring system. | |||||||||||||||||||||
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4-Epitetracycline-d6 | 4-Epitetracycline-d6 is deuterated labeled 4-Epitetracycline hydrochloride (HY-136443) 4-Epitetracycline hydrochloride is an epimer of Tetracycline (HY-A0107). Tetracycline can undergo epimerization insolution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity. | |||||||||||||||||||||
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References
- [1]. Daschner FD, et al. Combination of bacteriostatic and bactericidal drugs: lack of significant in vitro antagonism between penicillin, cephalothin, and rolitetracycline. Antimicrob Agents Chemother. 1976;10(5):802-808. [Content Brief]
- [2]. Howlett DR, et al. Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer beta-amyloid fibril formation. Biochem J. 1999;343 Pt 2(Pt 2):419-423. [Content Brief]
- [3]. Choudhary S, et al. Unraveling the energetics and mode of the recognition of antibiotics tetracycline and rolitetracycline by bovine serum albumin. Chem Biol Drug Des. 2012;80(5):693-705. [Content Brief]
