Infection

3-Deoxyanguibactin is a siderophore and Fe(III) chelator/iron delivery agent. 3-Deoxyanguibactin binds Fe(III) with 2:1 stoichiometry in liquid phase, delivers iron into Acinetobacter baumannii cells, and relies on the BauA outer membrane receptor and bau transport system for cellular entry. 3-Deoxyanguibactin can be used for the research of acinetobacter baumannii infection.

Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain.

Tirfipiravir is a nucleoside compound and antiviral agent, against the novel coronavirus or influenza virus.

LPRP-Et-97543 is a potent anti-HBV agent. LPRP-Et-97543 reduces Core, S, and preS but not X promoter activities. LPRP-Et-97543 can be used for acute and chronic HBV infections research.

Acacia farnesiana extract is an extract of Acacia farnesiana that can inhibit Mycobacterium tuberculosis and Shigella dysenteriae.

FAM labled Tomligisiran sodiumis a FAM labled Tomligisiran sodium.

Methyl undecanoate-d₂₁ is the d₂₁-labeled Methyl undecanoate (HY-W004285). Methyl undecanoate is a synthetic undecanoic acid ester analog with biting deterrent and repellent activity against Aedes aegypti mosquitoes, with a biting deterrent index (BDI) of 0.88 and minimum effective dose (MED) of 25 µg/cm². Methyl undecanoate can be used for the research of mosquito-borne diseases transmitted by Aedes aegypti.

Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC₅₀ of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1

FK-518 is a potent AmpC β-lactamase inhibitor. FK-518 demonstrates strong antimicrobial activity against P. aeruginosa strains overexpressing AmpC β-lactamase. FK-518 is promising for research of P. aeruginosa infections.

Kuwanon D is a prenylated flavanone found in the root bark of Morus alba L. Kuwanon D is predicted to be a high-affinity binder of SARS-CoV-2 main protease (Mpro), with favorable bioavailability and compliance with Lipinski's Rule of Five. Kuwanon D is an active component of Morus alba root bark identified as a lung cancer-related gene-targeting compound through network pharmacology screening. Kuwanon D is applicable to research related to COVID-19 and lung cancer.

Pravibismane (BisEDT; MBN-101) is a broad-spectrum topical anti-infective and anti-biofilm agent. Pravibismane disrupts bacterial bioenergetics by reducing bacterial concentrations of ATP in both planktonic and biofilm phenotypes and exhibits potent anti-biofilm activity against diabetic foot infections (DFI)-relevant pathogens, such as S. aureus and P. aeruginosa. Pravibismane can be used for the study of diabetic foot infections.

CouCyCF3 is a fluorescent probe for bacterial cytoplasmic pH, with a pKa of 7.0. CouCyCF3 can be taken up by both Gram-positive and Gram-negative bacteria. Under acidic conditions, the fluorescence of CouCyCF3 in the red channel increases, while its fluorescence in the blue channel increases with elevated pH. A linear quantitative response is achieved via the I_red/I_blue ratio within the pH range of 5.0-7.5, with excitation/emission wavelengths of 445/472 nm (blue) and 640/708 nm (red). CouCyCF3 can be used for studies on bacterial acid tolerance and phagolysosome acidification.

Caprochlorone has antiviral activity against orthopoxvirus. Caprochlorone can inhibit cell penetration by virus, also delays release of newly formed virus from the cell. Caprochlorone decreases the titers of influenza virus in infected-mice lungs.

HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC₅₀ values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity.

2,5-Dimethylhexane-3,4-diol is an active ingredient that can be extracted from Mansoa hirsuta. 2,5-Dimethylhexane-3,4-diol has antifungal activity in vitro. 2,5-Dimethylhexane-3,4-diol can be used for research on fungal infections.

Trichilin K is a insect antifeeding iimonoid found in the stem bark of Melia toosendan. Trichilin K displays antifeedant activity against Spodoptera eridania larvae.

Paenilagicin is a Gram-positive active antibiotic with a unique diphosphorylated prenyl binding mechanism that does not induce drug resistance. Paenilagicin exhibits a MIC value of 2 μg/mL against multidrug-resistant Gram-positive bacteria.

DprE1-IN-6 (Compound 56) is a DprE1 inhibitor. DprE1-IN-6 has anti-TB activity against Mtb H37Rv strain (MIC: 1 μM). DprE1-IN-6 also has antimycobacterial activity against drug-resistant strains. DprE1-IN-6 has high microsomal stability and medium clearance.

UC-38 (NSC-629243) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity.

Ledipasvir-d₆ is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC₅₀s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.62 μM.