Infection

N4-Acetylsulfamethoxazole-¹³C₆ (Acetylsulfamethoxazole-¹³C₆) is the ¹³C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections.

MsbA-IN-4 (compound 32) is a potent and highly selective MsbA inhibitor with an IC₅₀ value of 3 nM. MsbA-IN-4 has inhibitory activity against Escherichia coli with a MIC of 12 μM.

Spermine-¹⁵N₂ (NSC 268508-¹⁵N₂) is the ¹⁵N-labeled Spermine (HY-B1777). Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro.

HSV-1-IN-1 (compound 1b) is a drug candidate for herpes simplex virus HSV-1(IC₅₀=0.5 nM) and HSV-2(IC₅₀=16 nM) infection. HSV-1-IN-1 inhibits the helicase-primase complex to prevent viral replication, thereby inhibiting HSV infection.

Lysolipin I is a lipophilic antibiotic from Streptomyces violaceoniger. Lysolipin I is active against Gram-positive and Gramnegative bacteria.

Sporothriolide is a metabolite produced by Nodulisporium sp. A21. Sporothriolide has potently antifungal against R. solani and S. sclerotiorum, with EC₅₀ values of 11.6 μM and 10.7 μM, respectively. Sporothriolide inhibits conidium germination of Magnaporthe oryzae in vitro and in vivo.

Benzoic acid-d is the deuterium labeled Benzoic acid (HY-N0216). Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.

Bromodiphenhydramine (Ambodryl) is a potent antihistamine with antimicrobial property. Bromodiphenhydramine inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine can be used for cutaneous allergies research.

Aralia-saponin I is a saponin that can be isolated from Aralia elata, possessing high binding affinity for aerolysin and capable of binding to amino acids critical for aerolysin function. Aralia-saponin I can be utilized in research on infections caused by Aeromonas hydrophila.

MmpL3-IN-6 is a mycobacterial membrane protein large 3 (MmpL3) transporter inhibitor and is an antitubercular agent. MmpL3-IN-6 exerts bactericidal activity against replicating Mycobacterium tuberculosis.MmpL3-IN-6 retains activity against drug-resistant Mycobacterium tuberculosis.MmpL3-IN-6 can be used for the research of tuberculosis.

Altromycin A is a natural Pluramycin-like antibacterial agent.

DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC₅₀=22.491 nM; EC₅₀=0.256 nM). DGKα-IN-8 can be used to study cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection.

Tomligisiran sodium is a siRNA in JNJ-3989 (JNJ-73763989). JNJ-3989 is comprised of 2 siRNAs (Daplusiran and Tomligisiran), that target hepatitis B virus (HBV) mRNAs for degradation, thereby inhibiting HBV replication.

Thalrugosaminine is a benzylisoquinoline alkaloid isolated from the roots of Thalictrum minus. Thalrugosaminine shows good antibacterial activity with MIC values of 64-128 µg/ml.

Tetranor-Misoprostol is a derivative of Moxifloxacin (HY-66011A) and the active metabolite of a prostaglandin E1 analog. Moxifloxacin is an 8-methoxyquinolone antibacterial antibiotic used in the research of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and infectious pneumonia.

Clemontanoside-C is an oleanane-based triterpenoid saponin and antifungal agent found in the roots of Lepidagathis cuspidata. Clemontanoside-C acts against Aspergillus flavus, Rhizopus stolinifer, Penicillum nodatum, and Aspergillus fumigatus. Clemontanoside-C can be used for the research of fungal infections.

Florfenicol amine hydrochloride (Standard) is the analytical standard of Florfenicol amine hydrochloride (HY-118099). This product is intended for research and analytical applications. Florfenicol amine hydrochloride is the major metabolite of Florfenicol (HY-B1374) and serves as a marker residue in studies of the in vivo disposition and residue depletion of Florfenicol. Florfenicol amine hydrochloride is eliminated more slowly than the parent compound and persists in plasma and tissues. Florfenicol amine hydrochloride is used in veterinary research for studies on the metabolism, pharmacokinetics, and residue depletion of Florfenicol.

Diphylloside A is a flavonoid compound with antioxidant activity. Diphylloside A exhibits significant antibacterial activity against Pseudomonas aeruginosa.

PARP7-IN-26 (Compound 1) is a PARP7 inhibitor. PARP7-IN-26 forms a stable cocrystal with oxalic acid through hydrogen bonding, thereby increasing its stability. PARP7-IN-26 can be used in research related to cancer and viral infections.

Dichlorodiaporthin (Dichlorodiaportin) is an isocoumarin metabolite found in cultures of Penicillium nalgiovense. Dichlorodiaporthin acts as an antibacterial agent against various bacterial species.