Infection

Dendryphiellin D is a compound isolated from fungus Septoria rudbeckiae, a plant pathogenic fungus isolated from the halophyte Karelinia caspia. Dendryphiellin D significantly inhibits the production of nitric oxide (NO).

Methyl lucidenate Q is a methyl lucidenate. Methyl lucidenate Q shows potent inhibitory effects on EBV-EA induction.

PRP020 is a potent and specific inhibitor of mycobacterial ATP synthase. PRP020 does not inhibit acidification driven by succinate. PRP020 exihibits MIC₉₅ against M. tuberculosis of 2 μM, and it remains active against most drug-resistant mutant strains. PRP020 is highly safe and can be used in anti-tuberculosis research.

DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC₅₀=22.491 nM; EC₅₀=0.256 nM). DGKα-IN-8 can be used to study cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection.

Di-Val-L-dC, a prodrug of L-deoxycytidine, is a selective and specific anti-HBV agent.

2-Hydroxy-3-(hydroxymethyl)-6-(3-hydroxy-2-oxopropyl)-4-methoxybenzaldehyde (compound 3) is a potent antimicrobial agent isolated from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89. 2-Hydroxy-3-(hydroxymethyl)-6-(3-hydroxy-2-oxopropyl)-4-methoxybenzaldehyde exhibits an MIC value of 64 µg/mL against both Cryptococcus neoformans and methicillin-resistant Staphylococcus aureus (MRSA). 2-Hydroxy-3-(hydroxymethyl)-6-(3-hydroxy-2-oxopropyl)-4-methoxybenzaldehyde shows no cytotoxicity toward non-cancerous Vero cells.

Latarcin 2a is a linear cationic antibacterial peptide that can be isolated from the venom of the spider Lachesana tarabaevi, with broad-spectrum antibacterial activity. Latarcin 2a has a MIC of 0.5 μM for both Bacillus subtilis and Escherichia coli. Latarcin 2a is often used in the research of infectious conditions.

Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus).

Hydroxyphenyllactic acid-d₃ is the deuterium labeled Hydroxyphenyllactic acid (HY-113219). Hydroxyphenyllactic acid is an antifungal metabolite.

Milrinone solution is mainly composed of Milrinone (HY-14252). Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.

Antiviral agent 68 (Compound 3) is a diarylheptanoid that can be isolated from Alpinia katsumadai. Antiviral agent 68 has weak inhibitory activity against the neuraminidase of influenza virus A/PR/8/34, with an IC₅₀ of 29.75 μM.

Sanggenol P, a flavonoid, shows anti-HBV activity on HepG2.2.15 cell line in vitro.

Tagetes oil is an organic essential oil extracted from the Tagetes plant exhibiting inherent anti-inflammatory and antimicrobial attributes. Its employment in the research of diverse skin infections, wounds and dermatological conditions has been extensively recognized.

(D-Ala)-Peptide T is an octapeptide derived from gp120. (D-Ala)-Peptide T releases chemokines and prevents HIV-1 GP120-induced neuronal death. (D-Ala)-Peptide T can be used in research on infectious and neurological diseases such as AIDS-related dementia.

Psoralenol is a binder with strong binding affinity for ACTB and AKT1. Psoralenol forms stable complexes with ACTB and AKT1 through hydrogen bonding and protein interactions. Psoralenol exhibits larvicidal activity against brine shrimp. Psoralenol inhibits methicillin-resistant Staphylococcus aureus, Vibrio parahaemolyticus, Candida albicans, and Pseudomonas aeruginosa. Psoralenol can be used in research related to chronic obstructive pulmonary disease, bacterial infections, and fungal infections.

Lamivudine impurity 9 is an L-oxathiolanyl nucleoside. Lamivudine impurity 9 exhibits anti-HIV-1 activity with EC₅₀ > 100 μM in human peripheral blood mononuclear cells, and it shows no cytotoxicity even at concentrations up to 100 μM in human peripheral blood mononuclear cells and Vero cells.

Antibacterial agent 348 is an antimicrobial agent containing piperazine-isopropanolamine bifunctional groups. Antibacterial agent 348 suppresses virulence factor expression in plant pathogens. Antibacterial agent 348 compromises bacterial membrane integrity, leading to cytoplasmic leakage. Antibacterial agent 348 inhibits cellular proliferation of plant pathogens, diminishes colonization and infectivity of plant pathogens in host plants. Antibacterial agent 348 can be used for the research of rice bacterial leaf blight, pepper phytophthora blight.

AAP-SO2 is a Bactericide and Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) inhibitor, with an IC₅₀ of 0.025 μM against Mtb RNAP. AAP-SO2 allosterically slows the nucleotide addition rate during transcriptional elongation and enhances transcription termination efficiency. AAP-SO2 exhibits increased activity against β^S450L-type Mtb, possesses activity against non-replicating Mtb, and shows whole-cell activity against Mtb and related mycobacterial species. AAP-SO2 reduces the overall emergence rate of Rifampicin (HY-B0272) tolerance in Mtb, alters the mutation spectrum, and decreases the proportion of β^S450L-type Rifampicin-resistant mutants. AAP-SO2 acts synergistically with Rifampicin to kill non-replicating Mtb in a rabbit caseous necrosis model. AAP-SO2 can be used for the research of tuberculosis.

PNU-103657 (Compound 13) is an orally active reverse transcriptase inhibitor (IC₅₀ = 0.51 μM (WT)). PNU-103657 has antiviral activity. PNU-103657 can be used in research on infections and immune system diseases such as HIV infection.

Neuraminidase-IN-20 (Compound 5i) is a potent inhibitor of mutant neuraminidase (NA) (H5N1-H274Y) (IC₅₀= 0.44 μM).Neuraminidase-IN-20 binds to the 430 cavity site of NA and disrupts the enzymatic activity of NA.