Infection

Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC₅₀ value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC₅₀=80.95 μM).

DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC₅₀=22.491 nM; EC₅₀=0.256 nM). DGKα-IN-8 can be used to study cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection.

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection.

Florfenicol amine hydrochloride (Standard) is the analytical standard of Florfenicol amine hydrochloride (HY-118099). This product is intended for research and analytical applications. Florfenicol amine hydrochloride is the major metabolite of Florfenicol (HY-B1374) and serves as a marker residue in studies of the in vivo disposition and residue depletion of Florfenicol. Florfenicol amine hydrochloride is eliminated more slowly than the parent compound and persists in plasma and tissues. Florfenicol amine hydrochloride is used in veterinary research for studies on the metabolism, pharmacokinetics, and residue depletion of Florfenicol.

PARP7-IN-26 (Compound 1) is a PARP7 inhibitor. PARP7-IN-26 forms a stable cocrystal with oxalic acid through hydrogen bonding, thereby increasing its stability. PARP7-IN-26 can be used in research related to cancer and viral infections.

Anti-neuroinflammation agent 2 (compound 4) demonstrates anti-neuroinflammatory and antibacterial activities, with IC₅₀ values of 3.06 µM for TNF-α and 4.31 µM for IL-6, alongside EC₅₀ values ranging from 0.87 to 3.16 µM against Gram-positive bacteria.

d-WRL is a cationic antimicrobial peptide with properties such as salt resistance, protease resistance and no induction of drug resistance. As a membrane lytic agent, d-WRL effectively kills planktonic MRSA, mature MRSA biofilms and Pseudomonas aeruginosa. d-WRL selectively interacts with negatively charged bacterial membranes, causing changes in membrane permeability, structural disintegration and leakage of intracellular substances, thereby precisely lysing bacteria without damaging zwitterionic mammalian cell membranes. d-WRL inhibits and eliminates mature MRSA biofilms, and can be used in studies of methicillin-resistant Staphylococcus aureus (MRSA) infections.

Haenamindole is an alkaloid. Haenamindole is promising for research of bacterial infection and cancers.

FPI-1602 is a β-lactamase inhibitor. FPI-1602 displays marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp..

QKY-613 is a prodrug that enhances immune surveillance by targeting nucleic acid modification pathways. QKY-613 promotes the selective incorporation of 6mdA (N6-methyldeoxyadenosine) into viral DNA, enhancing the phase separation potential of DNA, thereby increasing the activation of cGAS and strengthening host immune surveillance. In virus-infected mouse models, QKY-613 significantly reduced mortality in aged mice. QKY-613 holds promise for research on nucleic acid modification-based immune surveillance mechanisms.

Moxifloxacin-d₅ (BAY 12-8039-d₅) TFA is the deuterated-labeled Moxifloxacin TFA. Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the stud of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.

Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC₅₀ of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1

Tetanus toxin (1301-1315) (C. tetani) is a C-terminal peptide fragment of tetanus toxin heavy chain from C. tetani. Tetanus toxin (1301-1315) (C. tetani) can be used for the researches of infection and immunology.

CDA-IN-3 (NCDI) is an inhibitor of chitin deacetylase (CDA) with anti-parasitic activity. CDA-IN-3 disrupts the chitin metabolism of nematodes, leading to an increase in the level of ROS in nematodes and causing cell damage. CDA-IN-3 has a significant inhibitory effect on all developmental stages of Caenorhabditis elegans. CDA-IN-3 can be used in the research of the anti-infection field .

N4-Acetylsulfamethoxazole-¹³C₆ (Acetylsulfamethoxazole-¹³C₆) is the ¹³C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections.

SLU-11695 is an orally active antiparasitic agent belonging to the pyrazolo[3,4-d]pyrimidine benzoxaborole class. SLU-11695 inhibits the asexual reproduction of Cryptosporidium parvum, eliminates parasite shedding, and prevents post-exposure recurrence. SLU-11695 can be used in the research of cryptosporidiosis.

CouCyCF3 is a fluorescent probe for bacterial cytoplasmic pH, with a pKa of 7.0. CouCyCF3 can be taken up by both Gram-positive and Gram-negative bacteria. Under acidic conditions, the fluorescence of CouCyCF3 in the red channel increases, while its fluorescence in the blue channel increases with elevated pH. A linear quantitative response is achieved via the I_red/I_blue ratio within the pH range of 5.0-7.5, with excitation/emission wavelengths of 445/472 nm (blue) and 640/708 nm (red). CouCyCF3 can be used for studies on bacterial acid tolerance and phagolysosome acidification.

HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC₅₀ values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity.

Phenethicillin (α-Phenoxyethylpenicillin) sodium is a Penicillin, and has antimicrobial activity.

Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC₅₀ (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research.