Infection

Griseochelin has anti-Gram-negative bacterial activity, and has inhibitory effect on coccidioides.

Pf20S-IN-1 is a selective inhibitor of the 20S proteasome β5 subunit of Plasmodium falciparum. Pf20S-IN-1 exhibits antiparasitic activity against Plasmodium falciparum, with an EC₅₀ of 20.1 nM against the Plasmodium falciparum W2 strain. Pf20S-IN-1 shows weak inhibitory effect on human 20S proteasome, has no obvious toxicity to human foreskin fibroblasts (HFF), and has a selectivity index > 25000. Pf20S-IN-1 can be used in malaria research.

Coclauril is an inhibitor of HBV. Coclauril inhibits HBV replication in the human hepatoblastoma cell line with an EC₅₀ of 7.6 μg/mL.

Pseudothymidine (Standard) is the analytical standard of Pseudothymidine (HY-101969). This product is intended for research and analytical applications. Pseudothymidine is a C-nucleoside analog of thymidine.

Laccaridione A can inhibit the activity of antiserine protease. Laccaridione A inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC₅₀s of 14.7 μg/mL, 2.5 μg/mL, 18.8 μg/mL, 7.2 μg/mL and 18.2 μg/mL, respectively.

Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities.

4-Hydroxybaumycinol A1 is an anthracycline antibiotic. 4-Hydroxybaumycinol A1 has anti-tumor activity.

DHODH-IN-34 (Compound 21q) is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ value of 13 nM. DHODH-IN-34 is promising for research of RNA viruses such as measles virus and chikungunya virus.

3-Hydroxypicolinic acid (Standard) is an analytical standard for 3-Hydroxypicolinic acid. This product is for research and analytical applications. 3-Hydroxypicolinic acid is a heterocyclic carboxylic acid ligand and cytotoxin, with a MIC₉₀ of >25 μg/mL against Mycobacterium tuberculosis H37Rv. 3-Hydroxypicolinic acid inhibits the growth of cancer cells and normal fibroblasts. 3-Hydroxypicolinic acid is applicable to research related to chronic myeloid leukemia, human lung adenocarcinoma, and tuberculosis.

Pacidamycin 2 has inhibitory effect on Pseudomonas aeruginosa. Pacidamycin 2 also has effect on a few strains of bacteria such as Suppurative staphylococcus and Escherichia coli.

sym-Homospermidine is a triamine polyamine and a structural analog of spermidine derived from plants. sym-Homospermidine can be taken up by bacteria and promotes the growth of Spe auxotrophic strains of Escherichia coli without inhibiting the growth of wild-type strains. sym-Homospermidine can be used in Escherichia coli-related research.

Inosamycin A is a broad-spectrum antimicrobial antibiotic.

Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria.

Tenellin is a fungal metabolite that has been found in Beauveria. It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes by 51, 57, and 74%, respectively, when used at a concentration of 200 μg/mL.1 Tenellin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of- 4.84 and 11.95 μM, respectively.

Oryzalin (Standard) is the analytical standard of Oryzalin (HY-147092). This product is intended for research and analytical applications. Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling.

Chloropropylate is an acaricide agent that can inhibit Mg²⁺ and Na⁺K⁺-ATPase.

Tert-Butyl cinnamate is a tert-butyl cinnamate with antifungal activity and comonomer function, which exhibits an average inhibition rate of 73.0% against phytopathogenic fungi at a concentration of 0.5 mM. Tert-Butyl cinnamate can be used in studies related to phytopathogenic fungal infections.

Antiparasitic agent-34 (Compound NO.6913) is an orally active antiparasitic agent. Antiparasitic agent-34 exhibits anti-S. mansoni activity in mice.

Liriodenine methiodide is an antibiotic that is active against C. albicans and S. cereuisiae with antimicrobial activities.

Tipifarnib (Standard) is the analytical standard of Tipifarnib (HY-10502). This product is intended for research and analytical applications. Tipifarnib (IND 58359) binds to and inhibits farnesyltransferase (FTase) with an IC₅₀ of 0.86 nM. Antineoplastic activity and antiparasitic activity.