Inflammation/Immunology

Ozanimod-d₆ (RPC-1063-d₆) is the deuterium labeled Ozanimod (HY-12288). Ozanimod (RPC-1063) is a CNS-penetrant sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P₁ and hS1P₅ receptor with EC₅₀s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS).

Tixanox sodium (RS-7540), an anti-allergic compound, is a potent inhibitor of mediator release in the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction.

Sulfacetamide-¹³C₆ (Sulphacetamide¹³C₆) is the ¹³C₆ labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities.

Serum CG probe 1 (formula (9)) is a compound for determining serum cholyglycine.

ZL0516 is a potent, selective, and orally active BRD4 BD1 inhibitor. ZL0516 suppresses inflammatory bowel disease (IBD) by inhibiting BRD4/NF-κB signaling.

TMV-IN-2, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-2 has antiviral activity against TMV with an EC₅₀ value of 89.9 μg/mL. TMV-IN-2 can be used for the research of infection, inflammation and tumor.

Salicylate hydroxylase, Microorganism (EC 1.14.13.1) is a flavin-dependent monooxygenase. Salicylate hydroxylase, Microorganism catalyzes the decarboxylative hydroxylation of salicylate into catechol in the naphthalene degradation pathway in Pseudomonas putida G7. Salicylate hydroxylase, Microorganism has potential biocatalytic applications.

ABT-182 is an antibody against human CCR8.

8,12-Iso-iPF2α-VI-1,5-lactone is a racemic mixture of the lactone form of the free acid 8,12-iso-iPF2α-VI, and is used in studies of immune-related diseases.

Sanguinarine (Standard) is the analytical standard of Sanguinarine. This product is intended for research and analytical applications. Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

RORγt inverse agonist 37 is an orally active RORγt inverse agonist with an IC₅₀ of 10.8 nM against human targets. RORγt inverse agonist 37 destabilizes helix 12 of RORγt in the agonist-bound conformation, thereby inhibiting transcriptional activity. RORγt inverse agonist 37 inhibits the secretion of IL-17 in cells and in LPS-induced systemic inflammation mouse models. RORγt inverse agonist 37 improves disease-related symptoms in mouse models of psoriasiform dermatitis. RORγt inverse agonist 37 can be used in research related to psoriasiform dermatitis and systemic inflammation.

Benzoylgomisin P is an anti-inflammatory agent.

MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT is a agent-linker conjugate for antibody-drug conjugate (ADC). MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT has the potential for cancer and autoimmune disease research.

11-Deoxy prostaglandin E1 (AY-23578; Doproston B) is an analog of prostaglandin E1 (PGE1) with bronchodilator activity. 11-Deoxy prostaglandin E1 inhibits histamine-induced bronchoconstriction and causes relaxation of tracheal strips in isolated guinea pigs.

BDDE-crosslinked sodium hyaluronate solution is mainly composed of BDDE (1,4‑butanediol diglycidyl ether). Its molecular weight and viscoelasticity are similar to those of normal joint synovial fluid. It can be used as a temporary substitute and supplement for joint fluid, alleviating pain in patients with knee osteoarthritis and improving the function of the knee joint.

Emedastine-¹³C,d₃ fumarate is the ¹³C- and deuterium labeled Emedastine. Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a K_i value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis.

Jacalin is a lectin, that can be extracted from jackfruit seeds. Jacalin interacts with human immunoglobulins and lymphocytes, and can be used in immunology research.

Prednisone 21-aldehyde/22-hydroxy Prednisone is a mixture of Prednisone 21-aldehyde (HY-167546) and 22-hydroxy prednisone.

Chitrakmool extract contains a variety of key active ingredients, including the potent naphthoquinone compound pampinidin, as well as various alkaloids, flavonoids, and terpenoids. Chitrakmool extract helps stimulate appetite, improve digestion, and relieve indigestion, bloating, and constipation.

GLP-1R agonist 44 is a glucagon-like peptide-1 receptor (GLP-1R) agonist. GLP-1R agonist 44 can be used for the research of diseases related to GLP-1R, such as type 2 diabetes, obesity, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, nephropathy, gout, hematuria, cardiovascular disease.