2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W267161
    (3R,4R)-3-Methyl-4-piperidinol 373604-43-4 98%
    (3R,4R)-3-Methyl-4-piperidinol is a PROTAC linker. (3R,4R)-3-Methyl-4-piperidinol can be used for the synthesis of PROTAC BCL6 Degrader-3 (HY-186067).
    (3R,4R)-3-Methyl-4-piperidinol
  • HY-W271506
    TMPO 10135-38-3 98%
    TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes.
    TMPO
  • HY-W272207
    AChE/BChE-IN-31 6338-81-4 98%
    AChE/BChE-IN-31 (Compound 3c) is a cholinesterase inhibitor. AChE/BChE-IN-31 exhibits certain inhibitory activity against hAChE and eqBChE. AChE/BChE-IN-31 also possesses antioxidant properties with an IC50 value of 105.04 μM against DPPH. AChE/BChE-IN-31 can be used in the research of diseases such as Alzheimer’s disease.
    AChE/BChE-IN-31
  • HY-W277900
    2-Methoxy-2,4-diphenylfuran-3-one 50632-57-0 98%
    2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading MMP-2 and MMP-9 by zymography.
    2-Methoxy-2,4-diphenylfuran-3-one
  • HY-W281862
    Sequifenadine 57734-69-7 98%
    Sequifenadine is a H1-antihistamine. Sequifenadine has the potential for the research of inflammatory eye disease with allergic symptoms.
    Sequifenadine
  • HY-W286423
    L-Pyroglutamic acid 7-amido-4-methylcoumarin 66642-36-2 98%
    L-Pyroglutamic acid 7-amido-4-methylcoumarin is a fluorogenic substrate for pyroglutamate aminopeptidase 1 (PGP-1).
    L-Pyroglutamic acid 7-amido-4-methylcoumarin
  • HY-W309310
    Etofesalamide 64700-55-6 98%
    Etofesalamide is a nonsteroidal antiinflammatory agent. Etofesalamide has major phase II metabolites of glucoside and riboside conjugations (such as etofesalamide-2-glucuronide) in filamentous fungi. Etofesalamide can be used for allergic and autoimmune skin diseases like toacne, psoriasis and sensitization dermatitis research.
    Etofesalamide
  • HY-W333234
    Clofenamic acid 13278-36-9 98%
    Clofenamic acid (2-(3-Chloroanilino)benzoic acid) is a nonsteroidal anti-inflammatory drug. Clofenamic acid can be used for the research of rheumatoid arthritis.
    Clofenamic acid
  • HY-W335927
    MAO-B-IN-19 152897-41-1 98%
    MAO-B-IN-19 is a selective MAO-B inhibitor with an IC50 of 0.67 μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties.
    MAO-B-IN-19
  • HY-W338346
    Salicylate choline 2016-36-6 98%
    Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid) (HY-14654). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer.
    Salicylate choline
  • HY-W339645
    Naproxen ethyl ester 31220-35-6 98%
    Naproxen ethyl ester ((S)-Naproxen ethyl ester) is a nonsteroidal anti-inflammatory drug with activity in relieving pain, fever, swelling and stiffness. Naproxen ethyl ester exerts its effects by inhibiting non-selective cyclooxygenase (COX). The R-(-)-isomer of Naproxen ethyl ester shows stronger immunogenicity, and the Michaelis-Menten parameter of its catalytic reaction is K(M)=6.67 mM, and the catalytic efficiency is 5.8 x 10^4 times higher than that of the non-catalytic reaction.
    Naproxen ethyl ester
  • HY-W342853
    HPSE-IN-1 58954-23-7 98%
    HPSE-IN-1 (Compound 31) is a heparanase inhibitor with an IC50 of 970 µM. HPSE-IN-1 can be used in the research of inflammatory diseases and cancer.
    HPSE-IN-1
  • HY-W344531
    Indomethacin glucuronide 75523-11-4 98%
    Indomethacin glucuronide is a glucuronide metabolite of Indomethacin (HY-14397).
    Indomethacin glucuronide
  • HY-W345148
    2-Naphthylamine-6,8-disulfonic acid potassium 842-15-9 98%
    2-Naphthylamine-6,8-disulfonic acid potassium is chemical that can be used for preparing dyestuff, medicine, agricultural chemicals etc.
    2-Naphthylamine-6,8-disulfonic acid potassium
  • HY-W357142
    3-Acetylumbelliferyl β-D-Glucopyranoside 20943-16-2 98%
    3-Acetylumbelliferyl β-D-Glucopyranoside is a fluorogenic substrate for β-glucosidase and can be used as a positive control substrates for β-D-glucosidase.
    3-Acetylumbelliferyl β-D-Glucopyranoside
  • HY-W371164
    C1s-IN-1 1016866-61-7 98%
    C1s-IN-1 (compound A1) is a selective and competitive inhibitor of C1s. C1s-IN-1 binds directly to C1s with a Kd of 9.8 μM.
    C1s-IN-1
  • HY-W385577
    (S)-2-Benzylpyrrolidine 97522-31-1 98%
    (S)-2-Benzylpyrrolidine (Compound s1) serves as a METH hapten scaffold. (S)-2-Benzylpyrrolidine attenuates Methamphetamine-induced hyperlocomotion, hyperthermia and respiratory depression. (S)-2-Benzylpyrrolidine alleviates Fentanyl-induced respiratory depression.
    (S)-2-Benzylpyrrolidine
  • HY-W387035
    D-α-Methyl DOPA 2799-15-7 98%
    D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. D-α-Methyl DOPA occupies a pocket along the DQ8 peptide binding groove. D-α-Methyl DOPA inhibits the binding of a DQ8 peptide to an MHC class II molecule for presentation to CD4+ T cells, thereby slowing the development or progression of type 1 diabete or celiac disease.
    D-α-Methyl DOPA
  • HY-W392413
    Glutathione monoethyl ester 118421-50-4 98%
    Glutathione monoethyl ester is a glutathione derivative that can be transported into cells and hydrolyzed into glutathione. Glutathione monoethyl ester downregulates the gene expression of TEN1 and CTC1 while upregulating TERT expression. Glutathione monoethyl ester enhances telomerase activity, promotes proliferation and differentiation in aged bone marrow stromal cells, while elevating glutathione levels and reducing oxidative stress, protein aggregation and cell death in motor neuronal cells. Glutathione monoethyl ester confers broad multi-organ protection against cerebral ischemia, renal injury, liver damage, and pancreatitis. Glutathione monoethyl ester can be used for the research of amyotrophic lateral sclerosis, stroke, acute renal failure, liver injury, and acute pancreatitis.
    Glutathione monoethyl ester
  • HY-W403075
    N-(3-Methoxybenzyl)stearamide 1429659-99-3 98.04%
    N-(3-Methoxybenzyl)stearamide a natural product from Lepidium meyenii (Maca), inhibits human and mouse soluble epoxide hydrolase (hsEH and msEH) with IC50s of 0.001 and <0.001 μg/nM, respectively.
    N-(3-Methoxybenzyl)stearamide
Cat. No. Product Name / Synonyms Application Reactivity