2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W012308
    2′-Hydroxydihydrochalcone 3516-95-8 99.50%
    2′-Hydroxydihydrochalcone (Compound 2a) is an anti-inflammatory agent. 2′-Hydroxydihydrochalcone can be synthesized from the reduction of Flavone (HY-N2424).
    2′-Hydroxydihydrochalcone
  • HY-W013727
    UK-78282 hydrochloride 136647-02-4 99.82%
    UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil.
    UK-78282 hydrochloride
  • HY-W014610
    Strawberry aldehyde 77-83-8 98%
    Strawberry aldehyde is an orally active synthetic flavor compound widely used in the food and cosmetics industries. Its presence in small cigar smoke shows a significant positive correlation with free radical levels, thereby increasing the toxicity of the smoke. Strawberry aldehyde has demonstrated long-term safety in rats.
    Strawberry aldehyde
  • HY-W015405
    4-Methylphthalic anhydride 19438-61-0 98%
    4-Methylphthalic anhydride is an organic acid anhydride and an immunogen/sensitizer. 4-Methylphthalic anhydride induces the production of specific immunoglobulin E and immunoglobulin G antibodies. 4-Methylphthalic anhydride is used in studies of occupational allergy.
    4-Methylphthalic anhydride
  • HY-W015697
    3-Methylquinoline 612-58-8 ≥98.0%
    3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC50 of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors.
    3-Methylquinoline
  • HY-W016937
    Moroxydine 3731-59-7 98%
    Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].
    Moroxydine
  • HY-W019720
    1-Methylguanidine hydrochloride 22661-87-6 98%
    1-Methylguanidine hydrochloride is a uremic toxin, which accumulate in dogs with renal failure and chronic kidney disese. 1-Methylguanidine hydrochloride enhances the oxidative metabolism and induces apoptosis in neutrophils.
    1-Methylguanidine hydrochloride
  • HY-W023253
    Biclotymol 15686-33-6 98%
    Biclotymol is an antimicrobial agent against gram-positive cocci. Biclotymol inhibits Streptococcus pneumoniae and Haemophilus influenzae, with MIC of 150 and 150 μM. Biclotymol exhibits anti-inflammatory and analgesic activity and ameliorates the otolaryngology infection and throat sore.
    Biclotymol
  • HY-W026082
    4-Ketobenztriazine-CH2COOH 97609-01-3 98%
    4-Ketobenztriazine-CH2COOH (compound BA) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 4-Ketobenztriazine-CH2COOH can be combined with carrier proteins and used in antigen design.
    4-Ketobenztriazine-CH2COOH
  • HY-W032938
    COX-1-IN-4 37928-17-9 98%
    COX-1-IN-4 (Compound P10) is a selective COX-1 inhibitor (IC50s: COX-1 = 0.09 μM; COX-2 = 2.49 μM). COX-1-IN-4 reduces the production of NO as well as the expression of the iNOS protein. COX-1-IN-4 can be used in the research of neuroinflammation.
    COX-1-IN-4
  • HY-W040175
    L-NASPA ammonium 799268-44-3 98%
    L-NASPA ammonium is a ophosphatidic acid (LPA) inhibitor useful in the study of platelet activation.
    L-NASPA ammonium
  • HY-W040176
    N-PTyrosine PA ammonium 799268-45-4 98%
    N-PTyrosine PA (N-Palmitoyl-tyrosine phosphoric acid) ammonium is a lysophosphatidic acid (LPA) receptor modulator, which exhibits weak inhibitory activity against LPA1 and partial agonist properties towards LPA5. N-PTyrosine PA ammonium inhibits the activation of LPA receptors and downstream responses by competing with agonists for binding sites. N-PTyrosine PA ammonium can induce morphological changes and aggregation, and also inhibit LPA-induced morphological changes through receptor desensitization caused by pre-incubation. N-PTyrosine PA ammonium can be used in the research of related diseases such as atherosclerosis and acute ischemic syndromes (e.g., unstable angina, myocardial infarction, stroke).
    N-PTyrosine PA ammonium
  • HY-W040232
    Dichlorodipropylstannane 867-36-7 98%
    Dichlorodipropylstannane is an immunomodulatory agent and significantly reduces the percentage of mouse peritoneal macrophages capable of ingesting yeast.
    Dichlorodipropylstannane
  • HY-W042654
    BnO-PEG6-OH 24342-68-5 99.88%
    BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BnO-PEG6-OH is also a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    BnO-PEG6-OH
  • HY-W049802
    N-((Allyloxy)carbonyl)-N-methyl-L-alanine 918531-01-8 98%
    N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. N-((Allyloxy)carbonyl)-N-methyl-L-alanine can be used for the synthesis of inhibitors of complement factor D. Complement factor D inhibitors can be used in the research of immune system related disease.
    N-((Allyloxy)carbonyl)-N-methyl-L-alanine
  • HY-W063263
    1-Acetylpyrrolidine 4030-18-6 99.54%
    1-Acetylpyrrolidine (N-acetylpyrrolidine) is a smoking-related metabolite. 1-Acetylpyrrolidine can induce low methylation at DNA CpG site. 1-Acetylpyrrolidine can be used for the research on the mechanisms of smoking-related diseases and the development of biomarkers.
    1-Acetylpyrrolidine
  • HY-W069974
    Ca2+ -Langerin-IN-1 79932-56-2 98%
    Ca2+-Langerin-IN-1 (Compound 3) is a allosteric Langerin inhibitor. Langerin is a C-type lectin that is expressed on Langerhans cells and plays a crucial role in pathogen recognition and innate immune activation. The KD value of the CRD domain of murine Langerin protein for Ca2+-Langerin-IN-1 is 17 μM under the presence of Ca²⁺ and 53 μM under the absence of Ca²⁺ competition. Ca2+-Langerin-IN-1 induces conformational changes and competitively replaces Ca²⁺, thereby inhibiting the carbohydrate recognition function of the protein. Ca2+-Langerin-IN-1 can be used in the research of immunomodulatory therapy.
    Ca2+ -Langerin-IN-1
  • HY-W091169
    N-Methyl-2-HOBA hydrochloride 63989-87-7 99.62%
    N-Methyl-2-HOBA (2-((Methylamino)methyl)phenol) hydrochloride is a methylated form of the isoketal scavenger 2-HOBA (HY-34350). N-Methyl-2-HOBA hydrochloride can be used as a negative control for the activity of 2-HOBA in a mouse model of hypertension.
    N-Methyl-2-HOBA hydrochloride
  • HY-W104862
    4-Amino-D-phenylalanine 102281-45-8 99.74%
    4-Amino-D-phenylalanine ([D-Phe(4-NH2)), a cyclic pentapeptide, inhibits CXCL12 binding to CXCR4 in FC131, with an IC50 of 0.1 μM.
    4-Amino-D-phenylalanine
  • HY-W109107
    GED 0507-34-Levo 921195-93-9 98%
    GED 0507-34-Levo is an orally active PPARγ modulator. GED 0507-34-Levo downregulates the expression of TGF-β, Smad3, IL-13, and CTGF in the colon. GED 0507-34-Levo improves DSS-induced chronic colitis and fibrosis.
    GED 0507-34-Levo
Cat. No. Product Name / Synonyms Application Reactivity