1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
  3. DHODH-IN-13

DHODH-IN-13 

Cat. No.: HY-135677
Handling Instructions

DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis.

For research use only. We do not sell to patients.

DHODH-IN-13 Chemical Structure

DHODH-IN-13 Chemical Structure

CAS No. : 1364791-86-5

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Description

DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis[1].

IC50 & Target

IC50: 4.3 μM for (Rat liver DHODH)[1]

In Vitro

DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds[1].

Molecular Weight

273.17

Formula

C₁₀H₆F₃N₃O₃

CAS No.

1364791-86-5

SMILES

O=C(C1=NONC1=O)NC2=CC=C(C(F)(F)F)C=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DHODH-IN-13Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHhydroxyfurazanLeflunomideA771726ratantiinflammatoryrheumatoidarthritisInhibitorinhibitorinhibit

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