Metabolic Disease

The intestinal cell kinase (ICK) protein belongs to the ros-cross hybridizing kinase (RCK) family. ICK is a ciliary protein, involved in ciliogenesis and regulation of intraflagellar transport (IFT). ICK Recombinant Human Active Protein Kinase is a recombinant ICK protein that can be used to study ICK-related functions.

LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer.

7-Hydroxyoctadecanoyl-CoA (7-Hydroxyoctadecanoyl-coenzyme A) is a coenzyme A derivative.

(3S)-3-Hydroxyoleoyl-CoA ((3S)-3-Hydroxyoleoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (3S)-3-hydroxyoleic acid.

Liposomal Vitamin B2 is a specialized delivery system that encapsulates vitamin B2 within tiny liposomes. These liposomes act as protective shells, enhancing the absorption and bioavailability of vitamin B2. Vitamin B2 (Riboflavin) is a water-soluble vita

11-Methyltetracosanoyl-CoA (11-Methyltetracosanoyl-coenzyme A) is a coenzyme A derivative.

3-Methylnonadecanoyl-CoA (3-Methylnonadecanoyl-coenzyme A) is a derivative of coenzyme A.

8-Methyltridecanoyl-CoA (8-Methyltridecanoyl-coenzyme A) is a coenzyme A derivative.

Z1456467176 is an allosteric inhibitor of P2X7R. Z1456467176 binds to P2X7R, prevents ATP-induced channel opening and receptor activation, and blocks ATP-induced activation of the NLRP3-caspase-1-IL-1β pathway. Z1456467176 inhibits ATP-induced P2X7R pore formation in macrophages, as well as IL-1β secretion induced by ATP or BzATP. Z1456467176 alleviates gouty joint inflammation in rats. Z1456467176 can be used for the research of gouty arthritis.

UE2316 is an orally active and specific 11βHSD1 inhibitor. UE2316 significantly improves glucose tolerance and insulin sensitivity in uremic rats. UE2316 also exacerbates hepatic fibrosis in mice. UE2316 can be used in the research of diseases such as hepatic fibrosis, uremia and diabetes mellitus.

l-α-tocopherol acetate-¹³C₄,d₆ is the ¹³C- and deuterium-labeled l-α-tocopherol acetate. l-α-tocopherol acetate is a natural tocopherol and has potent antioxidant activities.

L-Metanephrine is a nucleoside metabolite.

α-Glucosidase-IN-81 (Compound 5) is a potent α-Glucosidase inhibitor with an IC₅₀ value of 5.30 μM. α-Glucosidase-IN-81 is promising for research of diabetes.

BM-131246 is an oral antidiabetic agent.

Succinamide-CoA (Succinamide-coenzyme A) is a coenzyme A derivative.

2-Oxoglutaryl-CoA (2-Oxoglutaryl-coenzyme A) is a coenzyme A derivative.

NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC₅₀=30 μM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density.

Glucocorticoid receptor modulator 3 (Payload 6) is a thioester-containing glucocorticoid receptor modulator (IC₅₀=0.6 nM). Glucocorticoid receptor modulator 3 is designed to inactivate unconjugated payloads rapidly through liver metabolism, thereby minimizing systemic exposure. Glucocorticoid receptor modulator 3 can be utilized in the development of antibody-drug conjugates (ADCs) targeting autoimmune diseases.

Pparδ agonist 8 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 8 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2021169769A1, compound TM2).

Zuclomiphene-d₅ citrate is the deuterium labeled Zuclomiphene citrate (HY-B1617A). Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease.