Metabolic Disease

Catalase, Murine (EC 1.11.1.6) activates the decomposition of hydrogen peroxide, a reactive oxygen species, into water and oxygen. Catalase functions as a natural antioxidant, protecting cells against oxidative damage to proteins, lipids and nucleic acids.

BIM-23197 is a selective SST2 (IC₅₀ = 0.19 nM) agonist. BIM-23197 can effectively stimulate intracellular calcium mobilization in cells expressing SST2. BIM-23197 can be used for research on endocrine related conditions.

GW273297X is a selective CYP27A1 inhibitor. GW273297X blocks 27-hydroxycholesterol biosynthesis and sterol product formation in human macrophages. GW273297X reduces cancer cells colonization by inhibiting pro-metastatic effects of 27-hydroxycholesterol. GW273297X can be used for the researches of cancer and metabolic disease, such as breast cancer.

(Met(O)27)-Glucagon (1-29) (human, rat, porcine) is a modified glucagon. (Met(O)27)-Glucagon (1-29) (human, rat, porcine) has the same maximum glucose-synthesizing activity in rat hepatocytes as native glucagon, but it is less potent, suggesting a crucial role of methionine in the binding of glucagon to its hepatic receptor.

Resveratrol 12-C-β-glucopyranoside is a stilbene-type natural secondary metabolite. Resveratrol 12-C-β-glucopyranoside has the potential to target TNF-α, TGF-β1, and PPAR-α. As one of the core active components of MESR, Resveratrol 12-C-β-glucopyranoside exerts hepatoprotective, anti-inflammatory, and antioxidant effects in a rat liver injury model induced by Isoniazid (HY-B0329). Resveratrol 12-C-β-glucopyranoside can be used for studies related to drug-induced liver injury.

α2-3 Neuraminidase S, Streptococcus pneumoniae is a glycoside hydrolase enzyme that cleave the glycosidic linkages of neuraminic acids.

Pectate Lyase, Aspergillus sp. (EC 4.2.2.2) is an enzyme involved in the maceration and soft rotting of plant tissue. Pectate lyase is responsible for the eliminative cleavage of pectate, yielding oligosaccharides with 4-deoxy-α-D-mann-4-enuronosyl groups at their non-reducing ends.

Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC₅₀ values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity.

Ketoprofen L-thyroxine ester is a prodrug of Ketoprofen. Ketoprofen L-thyroxine ester reservoir and release ketoprofen slowly in the brain.

3-Ketopimelyl-CoA (3-Ketopimelyl-coenzyme A) is a coenzyme A derivative.

Propane-1,2,3-triyl tripalmitate (Standard) is the analytical standard of Propane-1,2,3-triyl tripalmitate (HY-W013061). This product is intended for research and analytical applications. Propane-1,2,3-triyl tripalmitate is a saturated fat. Propane-1,2,3-triyl tripalmitate enhances the lymphatic transport of Glycerol tristearate (HY-127035).

Beta-(2-naphthyl)-alanine-CoA (Beta-(2-naphthyl)-alanine-coenzyme A) is a coenzyme A derivative.

TRM-115 is a histamine H2 receptor antagonist. TRM-115 is promising for research of digestive system disease.

SB-435495 ditartrate is a potent, selective, reversible, non-covalent and orally active Lp-PLA₂ inhibitor with an IC₅₀ of 0.06 nM.

Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

GLP-1R agonist 28 (Compound 19) is an orally active GLP-1R agonist. GLP-1R agonist 28 can increase insulin secretion and can be used in the research of GLP-1R-related diseases.

6-phospho-D-gluconate dehydrogenase, E. coli (EC 1.1.1.44) is an oxidoreductase that acts on the CH-OH group of a donor molecule and uses NAD+ or NADP+ as an acceptor. The two substrates of 6-phospho-D-gluconate dehydrogenase, E. coli (EC 1.1.1.44) are 6-phospho-D-gluconate and NADP+, while its three products are D-ribulose-5-phosphate, CO2, and NADPH.

Immucillin-G is a purine nucleoside phosphorylase (PNP) inhibitor. Immucillin-G can reduce urate levels and can be used for the research of metabolic disease, such as hyperuricemia.

Human UGT1A3 is an UDP-glucuronosyltransferase. Human UGT1A3 catalyzes the glucuronidation of Estrone (HY-B0234), amine substrates, opioids, coumarins, flavonoids and anthraquinones. Human UGT1A3 binds to Chenodeoxycholic Acid (HY-76847) in the liver. Human UGT1A3 can be used in research related to cholestatic liver diseases.

Imidazole-5-propionic acid-¹³C₃ (Imidazolepropionic acid-¹³C₃) is the ¹³C-labeled Imidazole-5-propionic acid (HY-W045271). Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases.