Neurological Disease

GPR183 antagonist-4 is a potent and selective GPR183 antagonist with an IC₅₀ of 8.31 nM. GPR183 antagonist-4 inhibits receptor activation-mediated calcium signaling by antagonizing GPR183, and exhibits efficacy in ameliorating neuropathic pain-related allodynia. GPR183 antagonist-4 is useful for research on GPR183 signaling and neuropathic pain.

Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat.

PTP1B-IN-1 (Standard) (PTP1B inhibitor (Standard)) is the analytical standard of PTP1B-IN-1 (HY-10704). This product is intended for research and analytical applications. PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC₅₀ value of 1.6 mM. It is often used as the mother core for derivatives of analogues.

Netupitant (Standard) is the analytical standard of Netupitant. This product is intended for research and analytical applications. Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect.

VU 6008667 (Standard) is the analytical standard of VU 6008667 (HY-101281). This product is intended for research and analytical applications. VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration.

CP-66713 is a selective adenosine A2 receptor antagonist, with K_i of 22 nM. CP-66713 inhibits induction of long-term potentiation of evoked synaptic potentials. CP-66713 can be used in the study of neurological diseases.

Spectramide is a blood-brain barrier-permeable, reversible, and selective dopamine D₂ receptor ligand. Spectramide shows no strong interactions with dopamine D₁ receptors, dopamine uptake sites, adrenergic receptor systems, cholinergic receptor systems, or 5-HTR systems. Spectramide can be labeled with ¹¹C or ¹²³I isotopes for use in PET or SPECT. Spectramide preferentially accumulates in the striatum with low uptake in other brain regions, and its accumulation can be blocked by pre-administration of Haloperidol (HY-14538).

Bepridil hydrochloride (Standard) (CERM 1978 (Standard);Org 5730 hydrochloride (Standard)) is the analytical standard of Bepridil hydrochloride (HY-103315). This product is intended for research and analytical applications. Bepridil hydrochloride is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil hydrochloride modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoK_ATP/sarcK_ATP channels. Bepridil hydrochloride acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil hydrochloride alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil hydrochloride also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil hydrochloride is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection.

ASP7663 (Standard) is the analytical standard of ASP7663 (HY-101907). This product is intended for research and analytical applications. ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions.

Suberogorgin is a selective and reversible Acetylcholinesterase inhibitor. It is found in the Gorgoniae suberogorgia species from the South China Sea. Suberogorgin improves memory capacity in mice and reverses memory retention impairment induced by Cycloheximide (HY-12320) or Scopolamine (HY-N0296). It reduces urine output in rats and anesthetized cats. Suberogorgin increases respiratory rate, tidal volume, and minute ventilation in anesthetized cats, and exerts no significant effect on in vivo blood pressure in anesthetized cats. Suberogorgin is used in research related to memory disorders.

4,5-Desisopropylidene topiramate is the major metabolite of Topiramate (HY-B0122).

25T-NBOMe hydrochloride is a derivative of 2C-T having an N-(2-methoxybenzyl) addition at the amine.